MYO1G promoter hypomethylation correlates with its mRNA expression, lymphocyte infiltration, and immunotherapy response in melanoma

MYO1G promoter hypomethylation correlates with its mRNA expression, lymphocyte infiltration, and immunotherapy response in melanoma

ObjectivesMyosin IG (MYO1G) plays a vital role in triggering an immune response via regulating T cell migration to detect antigen-presenting cells. However, the biological and clinical significance of MYO1G DNA methylation and gene expression in melanoma and its immune microenvironment remains unkno...

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Bibliographic Details
Main Authors: Yonghua Xia, Yushu Zhang, Chenxi Zheng, Junbo Wang, Wenyu Di, Mengjie Zhang, Minglei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
immune cell infiltration
promoter methylation
MYO1G
immune checkpoint
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1585450/full
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