The role of gut microbiota and its metabolites short-chain fatty acids in food allergy
Emerging evidence indicated that the increase in food allergy (FA) over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota. Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbi...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022001902 |
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| author | Chen Chen Chenglong Liu Ke Zhang Wentong Xue |
| author_facet | Chen Chen Chenglong Liu Ke Zhang Wentong Xue |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | Emerging evidence indicated that the increase in food allergy (FA) over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota. Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbiota promoted the occurrence of FA. Recent research suggested that short-chain fatty acids (SCFAs), the main metabolites derived from gut microbiota, contributed to FA protection. Herein, we provided a comprehensive review on the relationship between gut microbiota and FA. The multifaceted mechanisms underlying beneficial effects of gut microbiota composition/metabolites on the regulation of diverse cellular pathways in intestinal epithelial cells, dendritic cells, innate lymphoid cells, T cells, B cells and mast cells in the immune system were discussed systematically. These findings emphasized the positive function of gut microbiota in FA and provided novel ideas for the treatment or prevention of FA in the future. |
| format | Article |
| id | doaj-art-74d98e7bdbb545fdb432ffb94256ab91 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-74d98e7bdbb545fdb432ffb94256ab912025-02-03T02:34:36ZengTsinghua University PressFood Science and Human Wellness2213-45302023-05-01123702710The role of gut microbiota and its metabolites short-chain fatty acids in food allergyChen Chen0Chenglong Liu1Ke Zhang2Wentong Xue3College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCorresponding author at: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaEmerging evidence indicated that the increase in food allergy (FA) over the past few decades was associated with the abnormal compositional and metabolic changes of gut microbiota. Gut microbiota played a vital role in maintaining the homeostasis of the immune system and the dysbiosis of gut microbiota promoted the occurrence of FA. Recent research suggested that short-chain fatty acids (SCFAs), the main metabolites derived from gut microbiota, contributed to FA protection. Herein, we provided a comprehensive review on the relationship between gut microbiota and FA. The multifaceted mechanisms underlying beneficial effects of gut microbiota composition/metabolites on the regulation of diverse cellular pathways in intestinal epithelial cells, dendritic cells, innate lymphoid cells, T cells, B cells and mast cells in the immune system were discussed systematically. These findings emphasized the positive function of gut microbiota in FA and provided novel ideas for the treatment or prevention of FA in the future.http://www.sciencedirect.com/science/article/pii/S2213453022001902Gut microbiotaCompositionShort-chain fatty acidsImmune systemFood allergy |
| spellingShingle | Chen Chen Chenglong Liu Ke Zhang Wentong Xue The role of gut microbiota and its metabolites short-chain fatty acids in food allergy Food Science and Human Wellness Gut microbiota Composition Short-chain fatty acids Immune system Food allergy |
| title | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy |
| title_full | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy |
| title_fullStr | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy |
| title_full_unstemmed | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy |
| title_short | The role of gut microbiota and its metabolites short-chain fatty acids in food allergy |
| title_sort | role of gut microbiota and its metabolites short chain fatty acids in food allergy |
| topic | Gut microbiota Composition Short-chain fatty acids Immune system Food allergy |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022001902 |
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