Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland

Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland

Abstract Secretory carcinomas (SCs) of the salivary gland have recently been recognized as low-grade, malignant tumors. Before this designation, most SCs were diagnosed as variants of acinic cell carcinomas (AciCCs). SCs harbor the t(12;15)(p13;q25) translocation that generates an oncogenic fusion g...

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Main Authors: Ryo Kawaura, Tomohiko Ishikawa, Hirofumi Shibata, Masashi Kuroki, Kazuhiro Kobayashi, Yuki Hanamatsu, Tatsuhiko Miyazaki, Hiroyuki Tomita, Takuma Ishihara, Hajime Usubuchi, Yayoi Aoyama, Yukinori Asada, Takayuki Imai, Akira Ohkoshi, Akira Hara, Yukio Katori, Toru Furukawa, Takenori Ogawa
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Salivary gland
Secretory carcinoma
Acinic cell carcinoma
ETV6:NTRK3 fusion gene
S-100
Mammaglobin
Online Access:https://doi.org/10.1007/s12672-025-03072-3
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Summary:Abstract Secretory carcinomas (SCs) of the salivary gland have recently been recognized as low-grade, malignant tumors. Before this designation, most SCs were diagnosed as variants of acinic cell carcinomas (AciCCs). SCs harbor the t(12;15)(p13;q25) translocation that generates an oncogenic fusion gene, ETS variant transcription factor 6/Neurotrophic tyrosine receptor kinase(ETV6::NTRK3). However, detecting fusion genes in a clinical setting is time-consuming and costly. In this study, we examined 31 cases previously diagnosed as AciCC and SC using pathological analyses with detection of fusion genes using ETV6 break-apart fluorescence in-situ hybridization and reverse transcription-polymerase chain reaction. After re-analysis, we found that these 31 cases actually comprised 21 SCs and 10 AciCCs. We examined the diagnostic utility of immunohistochemistry by comparing results with the fusion gene, Pan-Trk, which despite having recently been reported as effective for diagnosis of SC, was not universally accurate. However, combining mammaglobin and S-100 could be particularly useful in diagnosing SC. This practical method will contribute to accurate diagnosis of SCs, while saving time in daily clinical practice.
ISSN:2730-6011

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