Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis

Abstract Background Cancer-associated fibroblasts (CAFs) have been identified to drive chemotherapy resistance in triple-negative breast cancer (TNBC). This study evaluated the functions of CAFs-mediated suppressive ferroptosis in doxorubicin (DOX) resistance in TNBC and its detailed molecular mecha...

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Bibliographic Details
Main Authors: KeJing Zhang, Lei Guo, Xin Li, Yu Hu, Na Luo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
CAFs
DOX resistance
TNBC
Ferroptosis
Histone lactylation
ZFP64
Online Access:https://doi.org/10.1186/s12967-025-06246-3
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