Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve
Abstract Objective To explore the diagnostic value of crucial parameters of echocardiography for fetal bicuspid aortic valve (BAV) and improve diagnostic accuracy. Methods Fetuses with a prenatal suspected diagnosis of BAV were followed, and confirmed and misdiagnosed cases were obtained. Prenatal e...
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BMC
2025-01-01
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| Series: | Echo Research and Practice |
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| Online Access: | https://doi.org/10.1186/s44156-024-00065-w |
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| author | Min Zheng Yanping Ruan Lin Sun Xiaowei Liu Jiancheng Han Yihua He |
| author_facet | Min Zheng Yanping Ruan Lin Sun Xiaowei Liu Jiancheng Han Yihua He |
| author_sort | Min Zheng |
| collection | DOAJ |
| description | Abstract Objective To explore the diagnostic value of crucial parameters of echocardiography for fetal bicuspid aortic valve (BAV) and improve diagnostic accuracy. Methods Fetuses with a prenatal suspected diagnosis of BAV were followed, and confirmed and misdiagnosed cases were obtained. Prenatal echocardiography was reviewed and analyzed. ROC curves were plotted to evaluate the diagnostic capabilities of different echo signs. Results 14 cases were confirmed, and 7 patients were misdiagnosed. Some abnormal ultrasound signs were observed in both groups, including direct ultrasound signs of the aortic valve: Two commissures and a “fish-mouth” opening; Thickening, hyperechogenicity, or the presence of a raphe; Restricted motion or opening; Eccentric or a-linear valve leaflet closure line and indirect ultrasound signs: Increased supra-aortic valve velocity; Post-stenotic widening of the ascending aorta. The combination of “Increased supra-aortic valve velocity” and “Two commissures and a ‘fish-mouth’ opening” had the highest AUC (AUC: 0.893, 95%CI: 0.752-1.000, Sensitivity: 0.786, Specificity: 1.000). Conclusions We first found that the combination of “Increased supra-aortic valve velocity” and “Two commissures and a ‘fish-mouth’ opening” had the best diagnostic capability and could reduce the rate of misdiagnosis. Fetuses with BAV should be followed up prenatally for the aortic valve and ascending aorta as they progressively deteriorate with gestational age. |
| format | Article |
| id | doaj-art-74cf6e577a8b481aabd55f4695b808c4 |
| institution | Kabale University |
| issn | 2055-0464 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | Echo Research and Practice |
| spelling | doaj-art-74cf6e577a8b481aabd55f4695b808c42025-01-12T12:29:01ZengBMCEcho Research and Practice2055-04642025-01-011211810.1186/s44156-024-00065-wDiagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valveMin Zheng0Yanping Ruan1Lin Sun2Xiaowei Liu3Jiancheng Han4Yihua He5Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Objective To explore the diagnostic value of crucial parameters of echocardiography for fetal bicuspid aortic valve (BAV) and improve diagnostic accuracy. Methods Fetuses with a prenatal suspected diagnosis of BAV were followed, and confirmed and misdiagnosed cases were obtained. Prenatal echocardiography was reviewed and analyzed. ROC curves were plotted to evaluate the diagnostic capabilities of different echo signs. Results 14 cases were confirmed, and 7 patients were misdiagnosed. Some abnormal ultrasound signs were observed in both groups, including direct ultrasound signs of the aortic valve: Two commissures and a “fish-mouth” opening; Thickening, hyperechogenicity, or the presence of a raphe; Restricted motion or opening; Eccentric or a-linear valve leaflet closure line and indirect ultrasound signs: Increased supra-aortic valve velocity; Post-stenotic widening of the ascending aorta. The combination of “Increased supra-aortic valve velocity” and “Two commissures and a ‘fish-mouth’ opening” had the highest AUC (AUC: 0.893, 95%CI: 0.752-1.000, Sensitivity: 0.786, Specificity: 1.000). Conclusions We first found that the combination of “Increased supra-aortic valve velocity” and “Two commissures and a ‘fish-mouth’ opening” had the best diagnostic capability and could reduce the rate of misdiagnosis. Fetuses with BAV should be followed up prenatally for the aortic valve and ascending aorta as they progressively deteriorate with gestational age.https://doi.org/10.1186/s44156-024-00065-wCongenital heart diseaseBicuspid aortic valveFetusEchocardiographyFollow up |
| spellingShingle | Min Zheng Yanping Ruan Lin Sun Xiaowei Liu Jiancheng Han Yihua He Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve Echo Research and Practice Congenital heart disease Bicuspid aortic valve Fetus Echocardiography Follow up |
| title | Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve |
| title_full | Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve |
| title_fullStr | Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve |
| title_full_unstemmed | Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve |
| title_short | Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve |
| title_sort | diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve |
| topic | Congenital heart disease Bicuspid aortic valve Fetus Echocardiography Follow up |
| url | https://doi.org/10.1186/s44156-024-00065-w |
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