Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models
Background: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. Objective: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. Methods: In formaldeh...
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Elsevier
2018-12-01
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| Series: | Integrative Medicine Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422018301872 |
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| author | Himanshu Sharma Prerna Chauhan Surender Singh |
| author_facet | Himanshu Sharma Prerna Chauhan Surender Singh |
| author_sort | Himanshu Sharma |
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| description | Background: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. Objective: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. Methods: In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3 mg/kg, p.o.) and three groups, treated with 50, 100 and 200 mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis model, CFA was injected into the sub-plantar surface of the right hind paw in rats. Joint diameter was measured, and serum TNF-α and IL-1β were measured. Histopathological and immunohistochemical analyses were also performed. Results: CCHE treatment significantly (p < 0.01) reduced MDA levels and joint swelling in a concentration-dependent manner in rats with formaldehyde-induced arthritis, in which GSH levels were elevated (p < 0.01). In rats with CFA-induced arthritis, CCHE treatment significantly reduced joint swelling as well as IL-1β and TNF-α levels (p < 0.01). TNF-α receptor expression was decreased in rats treated with indomethacin or CCHE. Conclusion: Based on these findings, it can be concluded that C. cassia possesses anti-arthritic properties. Keywords: Arthritis, Cinnamomum cassia, Complete Freund's adjuvant, Indomethacin, Formaldehyde |
| format | Article |
| id | doaj-art-74c90bcb58c44bbf8a66c8d769e8fdaf |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-74c90bcb58c44bbf8a66c8d769e8fdaf2025-08-20T03:52:28ZengElsevierIntegrative Medicine Research2213-42202018-12-017436637310.1016/j.imr.2018.08.002Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental modelsHimanshu Sharma0Prerna Chauhan1Surender Singh2Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Pharmacology, All India Institute of Medical Sciences, New Delhi, IndiaCorresponding author. Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110062, India.; Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, IndiaBackground: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. Objective: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. Methods: In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3 mg/kg, p.o.) and three groups, treated with 50, 100 and 200 mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis model, CFA was injected into the sub-plantar surface of the right hind paw in rats. Joint diameter was measured, and serum TNF-α and IL-1β were measured. Histopathological and immunohistochemical analyses were also performed. Results: CCHE treatment significantly (p < 0.01) reduced MDA levels and joint swelling in a concentration-dependent manner in rats with formaldehyde-induced arthritis, in which GSH levels were elevated (p < 0.01). In rats with CFA-induced arthritis, CCHE treatment significantly reduced joint swelling as well as IL-1β and TNF-α levels (p < 0.01). TNF-α receptor expression was decreased in rats treated with indomethacin or CCHE. Conclusion: Based on these findings, it can be concluded that C. cassia possesses anti-arthritic properties. Keywords: Arthritis, Cinnamomum cassia, Complete Freund's adjuvant, Indomethacin, Formaldehydehttp://www.sciencedirect.com/science/article/pii/S2213422018301872 |
| spellingShingle | Himanshu Sharma Prerna Chauhan Surender Singh Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models Integrative Medicine Research |
| title | Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models |
| title_full | Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models |
| title_fullStr | Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models |
| title_full_unstemmed | Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models |
| title_short | Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models |
| title_sort | evaluation of the anti arthritic activity of cinnamomum cassia bark extract in experimental models |
| url | http://www.sciencedirect.com/science/article/pii/S2213422018301872 |
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