Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient
Development of autoantibodies against coagulation factors is an uncommon bleeding disorder associated with cancer, autoimmune conditions, pregnancy, or no apparent disease. Spontaneous FVIII inhibitors are the most frequently encountered; those against FXI have been only anecdotally reported. We rep...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/626831 |
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| author | Natale Vazzana Luca Scarti Chiara Beltrame Antonella Picchi Gianni Taccetti Alberto Fortini |
| author_facet | Natale Vazzana Luca Scarti Chiara Beltrame Antonella Picchi Gianni Taccetti Alberto Fortini |
| author_sort | Natale Vazzana |
| collection | DOAJ |
| description | Development of autoantibodies against coagulation factors is an uncommon bleeding disorder associated with cancer, autoimmune conditions, pregnancy, or no apparent disease. Spontaneous FVIII inhibitors are the most frequently encountered; those against FXI have been only anecdotally reported. We report a case of acquired FXI inhibitor presenting as fatal intracranial spontaneous bleeding in an elderly patient with history of cancer and previous transfusions. Few cases of acquired FXI inhibitor have been reported in association with connective tissue disease, cancer, or surgery. Bleeding includes mucocutaneous bleeding, postsurgical hemorrhage, or life-threatening events. Treatment consists of arresting the bleeding and inhibitor eradication. High degree of suspicion is essential to promptly diagnose and treat this uncommon condition. |
| format | Article |
| id | doaj-art-74c8f49ec7b44d62ae01ccd536b520b1 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-74c8f49ec7b44d62ae01ccd536b520b12025-08-20T02:07:20ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/626831626831Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly PatientNatale Vazzana0Luca Scarti1Chiara Beltrame2Antonella Picchi3Gianni Taccetti4Alberto Fortini5Department of Internal Medicine, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, ItalyDepartment of Internal Medicine, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, ItalyDepartment of Internal Medicine, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, ItalyDepartment of Clinical Chemistry, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, ItalyDepartment of Internal Medicine, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, ItalyDepartment of Internal Medicine, “S. Giovanni di Dio” Hospital, Via di Torregalli, 3-50143 Florence, ItalyDevelopment of autoantibodies against coagulation factors is an uncommon bleeding disorder associated with cancer, autoimmune conditions, pregnancy, or no apparent disease. Spontaneous FVIII inhibitors are the most frequently encountered; those against FXI have been only anecdotally reported. We report a case of acquired FXI inhibitor presenting as fatal intracranial spontaneous bleeding in an elderly patient with history of cancer and previous transfusions. Few cases of acquired FXI inhibitor have been reported in association with connective tissue disease, cancer, or surgery. Bleeding includes mucocutaneous bleeding, postsurgical hemorrhage, or life-threatening events. Treatment consists of arresting the bleeding and inhibitor eradication. High degree of suspicion is essential to promptly diagnose and treat this uncommon condition.http://dx.doi.org/10.1155/2014/626831 |
| spellingShingle | Natale Vazzana Luca Scarti Chiara Beltrame Antonella Picchi Gianni Taccetti Alberto Fortini Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient Case Reports in Hematology |
| title | Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient |
| title_full | Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient |
| title_fullStr | Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient |
| title_full_unstemmed | Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient |
| title_short | Acquired Factor XI Inhibitor Presenting as Spontaneous Bilateral Subdural Hematoma in an Elderly Patient |
| title_sort | acquired factor xi inhibitor presenting as spontaneous bilateral subdural hematoma in an elderly patient |
| url | http://dx.doi.org/10.1155/2014/626831 |
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