CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia
Introduction: The human immunodeficiency virus (HIV) compromises the immune system, making the monitoring of cluster of differentiation (CD4) counts and viral loads critical for assessing disease progression and opportunistic infection risks. Eye-related manifestations, such as uveitis, are common a...
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| Format: | Article |
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Faculty of Medicine, Universitas Airlangga
2025-07-01
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| Series: | Current Internal Medicine Research and Practice Surabaya Journal |
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| Online Access: | https://e-journal.unair.ac.id/CIMRJ/article/view/65918 |
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| author | Shofa Annesa Hidayat Ismi Zuhria Muhammad Vitanata Arfijanto Reni Prastyani |
| author_facet | Shofa Annesa Hidayat Ismi Zuhria Muhammad Vitanata Arfijanto Reni Prastyani |
| author_sort | Shofa Annesa Hidayat |
| collection | DOAJ |
| description | Introduction: The human immunodeficiency virus (HIV) compromises the immune system, making the monitoring of cluster of differentiation (CD4) counts and viral loads critical for assessing disease progression and opportunistic infection risks. Eye-related manifestations, such as uveitis, are common among HIV patients. The purpose of this study was to investigate the differences in CD4 count and viral load between HIV patients with infectious posterior uveitis and those without at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Methods: A retrospective study with an analytical observational design was conducted using the medical records of 75 HIV patients. The examined variables included CD4 count and viral load as independent variables, alongside the incidence and absence of infectious posterior uveitis as dependent variables. The inclusion criteria were HIV patients with regular follow-ups, thereby excluding those with irregular follow-ups. The analysis used the Mann-Whitney test, with p<0.05 indicating a statistically significant difference.
Results: All 75 samples met the inclusion criteria for analysis. The majority of the patients were male (64%) and within the age range of 31 to 40 years (44%). Patients with infectious posterior uveitis had significantly lower CD4 counts (p<0.05) compared to those without the disease. However, no significant differences in viral loads (p>0.05) were observed between patients with posterior uveitis and those without.
Conclusion: CD4 counts differ significantly between patients with infectious posterior uveitis and those without, while viral loads show no considerable differences.
Highlights:
1. This study highlights the differences in cluster of differentiation (CD4) lymphocyte count and viral load between HIV patients with infectious posterior uveitis and those without.
2. The findings may provide new insights into the immunological mechanisms underlying infectious posterior uveitis in persons living with HIV.
3. This work contributes to determining the factors that affect the development of infectious posterior uveitis and explores the potential use of CD4 lymphocyte count and viral load as biomarkers for the diagnosis and management of the disease. |
| format | Article |
| id | doaj-art-74c12a03ae3f41a5a2c8151e1b5068a5 |
| institution | DOAJ |
| issn | 2721-544X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Faculty of Medicine, Universitas Airlangga |
| record_format | Article |
| series | Current Internal Medicine Research and Practice Surabaya Journal |
| spelling | doaj-art-74c12a03ae3f41a5a2c8151e1b5068a52025-08-20T03:03:16ZengFaculty of Medicine, Universitas AirlanggaCurrent Internal Medicine Research and Practice Surabaya Journal2721-544X2025-07-01629910510.20473/cimrj.v6i2.6591864086CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in IndonesiaShofa Annesa Hidayat0https://orcid.org/0009-0000-6249-5051Ismi Zuhria1https://orcid.org/0000-0003-2102-7782Muhammad Vitanata Arfijanto2https://orcid.org/0000-0003-4510-755XReni Prastyani3https://orcid.org/0000-0002-8507-1689Medical Study Program, Faculty of Medicine, Universitas Airlangga, SurabayaDepartment of Ophthalmology, Faculty of Medicine, Universitas Airlangga; Dr. Soetomo General Academic Hospital, Surabaya; Indonesian Association of OphthalmologyDepartment of Internal Medicine, Faculty of Medicine, Universitas Airlangga; Dr Soetomo General Academic Hospital, SurabayaDepartment of Ophthalmology, Faculty of Medicine, Universitas Airlangga; Dr. Soetomo General Academic Hospital, SurabayaIntroduction: The human immunodeficiency virus (HIV) compromises the immune system, making the monitoring of cluster of differentiation (CD4) counts and viral loads critical for assessing disease progression and opportunistic infection risks. Eye-related manifestations, such as uveitis, are common among HIV patients. The purpose of this study was to investigate the differences in CD4 count and viral load between HIV patients with infectious posterior uveitis and those without at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Methods: A retrospective study with an analytical observational design was conducted using the medical records of 75 HIV patients. The examined variables included CD4 count and viral load as independent variables, alongside the incidence and absence of infectious posterior uveitis as dependent variables. The inclusion criteria were HIV patients with regular follow-ups, thereby excluding those with irregular follow-ups. The analysis used the Mann-Whitney test, with p<0.05 indicating a statistically significant difference. Results: All 75 samples met the inclusion criteria for analysis. The majority of the patients were male (64%) and within the age range of 31 to 40 years (44%). Patients with infectious posterior uveitis had significantly lower CD4 counts (p<0.05) compared to those without the disease. However, no significant differences in viral loads (p>0.05) were observed between patients with posterior uveitis and those without. Conclusion: CD4 counts differ significantly between patients with infectious posterior uveitis and those without, while viral loads show no considerable differences. Highlights: 1. This study highlights the differences in cluster of differentiation (CD4) lymphocyte count and viral load between HIV patients with infectious posterior uveitis and those without. 2. The findings may provide new insights into the immunological mechanisms underlying infectious posterior uveitis in persons living with HIV. 3. This work contributes to determining the factors that affect the development of infectious posterior uveitis and explores the potential use of CD4 lymphocyte count and viral load as biomarkers for the diagnosis and management of the disease.https://e-journal.unair.ac.id/CIMRJ/article/view/65918human immunodeficiency virus (hiv)posterior uveitiscluster of differentiation (cd4) lymphocytesviral load |
| spellingShingle | Shofa Annesa Hidayat Ismi Zuhria Muhammad Vitanata Arfijanto Reni Prastyani CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia Current Internal Medicine Research and Practice Surabaya Journal human immunodeficiency virus (hiv) posterior uveitis cluster of differentiation (cd4) lymphocytes viral load |
| title | CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia |
| title_full | CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia |
| title_fullStr | CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia |
| title_full_unstemmed | CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia |
| title_short | CD4 Count and Viral Load Differences in HIV Patients with and without Infectious Posterior Uveitis at a Tertiary Hospital in Indonesia |
| title_sort | cd4 count and viral load differences in hiv patients with and without infectious posterior uveitis at a tertiary hospital in indonesia |
| topic | human immunodeficiency virus (hiv) posterior uveitis cluster of differentiation (cd4) lymphocytes viral load |
| url | https://e-journal.unair.ac.id/CIMRJ/article/view/65918 |
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