Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials
Background: Obesity is a chronic condition and a global epidemic, associated with impaired intestinal permeability owing to dysbiosis. Gut microbiota reportedly plays a potential role in obesity treatment. Probiotics have emerged as the most widely used approach for treating dysbiosis. This study ex...
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| Language: | English |
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Elsevier
2025-12-01
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| Series: | Food Hydrocolloids for Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667025925000317 |
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| author | Alpha Fardah Athiyyah Triska Susila Nindya Reza Gunadi Ranuh Andy Darma Khadijah Rizky Sumitro Purwo Sri Rejeki Lilik Djuari Subijanto Marto Sudarmo Rina Agustina |
| author_facet | Alpha Fardah Athiyyah Triska Susila Nindya Reza Gunadi Ranuh Andy Darma Khadijah Rizky Sumitro Purwo Sri Rejeki Lilik Djuari Subijanto Marto Sudarmo Rina Agustina |
| author_sort | Alpha Fardah Athiyyah |
| collection | DOAJ |
| description | Background: Obesity is a chronic condition and a global epidemic, associated with impaired intestinal permeability owing to dysbiosis. Gut microbiota reportedly plays a potential role in obesity treatment. Probiotics have emerged as the most widely used approach for treating dysbiosis. This study explored the effect of oral probiotic supplementation on intestinal permeability in individuals with obesity. Methods: A Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, ScienceDirect, PLOS One, and Cochrane databases were searched to identify articles published between 2014 and September 2024. The Cochrane risk-of-bias tool for randomized trials was used to assess publication bias. Results: A total of 690 human RCTs (randomized controlled trials) were identified, of which nine were eligible for this review. Probiotics (Akkermansia, Bifidobacterium, Enterococcus, Lactobacillus, Streptococcus, and a combination of Saccharomyces yeast) used for over 8 weeks may decrease gut permeability outcomes, including plasma zonulin, fecal zonulin, plasma or serum LPS, urinary lactulose, and urinary mannitol; however, BMI (body mass index) levels exhibited inconsistent measurements across all groups. Conclusions: Probiotic supplementation for a minimum of 8 weeks may reduce gut permeability. However, further studies are required to develop standardized protocols for probiotic strains, dosages, durations, and delivery methods, to better understand their effects on intestinal permeability and related outcomes in individuals with obesity. |
| format | Article |
| id | doaj-art-74bfc09623bf486f8c2cb2f914db3182 |
| institution | OA Journals |
| issn | 2667-0259 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Hydrocolloids for Health |
| spelling | doaj-art-74bfc09623bf486f8c2cb2f914db31822025-08-20T02:07:19ZengElsevierFood Hydrocolloids for Health2667-02592025-12-01810022510.1016/j.fhfh.2025.100225Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trialsAlpha Fardah Athiyyah0Triska Susila Nindya1Reza Gunadi Ranuh2Andy Darma3Khadijah Rizky Sumitro4Purwo Sri Rejeki5Lilik Djuari6Subijanto Marto Sudarmo7Rina Agustina8Departement of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Departement of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia; Corresponding author.Departement of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, IndonesiaDepartement of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Departement of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartement of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Departement of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartement of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Departement of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaPhysiology Division, Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, IndonesiaDepartement of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, IndonesiaDepartement of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Departement of Child Health, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartement of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaBackground: Obesity is a chronic condition and a global epidemic, associated with impaired intestinal permeability owing to dysbiosis. Gut microbiota reportedly plays a potential role in obesity treatment. Probiotics have emerged as the most widely used approach for treating dysbiosis. This study explored the effect of oral probiotic supplementation on intestinal permeability in individuals with obesity. Methods: A Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, ScienceDirect, PLOS One, and Cochrane databases were searched to identify articles published between 2014 and September 2024. The Cochrane risk-of-bias tool for randomized trials was used to assess publication bias. Results: A total of 690 human RCTs (randomized controlled trials) were identified, of which nine were eligible for this review. Probiotics (Akkermansia, Bifidobacterium, Enterococcus, Lactobacillus, Streptococcus, and a combination of Saccharomyces yeast) used for over 8 weeks may decrease gut permeability outcomes, including plasma zonulin, fecal zonulin, plasma or serum LPS, urinary lactulose, and urinary mannitol; however, BMI (body mass index) levels exhibited inconsistent measurements across all groups. Conclusions: Probiotic supplementation for a minimum of 8 weeks may reduce gut permeability. However, further studies are required to develop standardized protocols for probiotic strains, dosages, durations, and delivery methods, to better understand their effects on intestinal permeability and related outcomes in individuals with obesity.http://www.sciencedirect.com/science/article/pii/S2667025925000317ProbioticGut permeabilityObeseRandomized controlled trialGut microbiota |
| spellingShingle | Alpha Fardah Athiyyah Triska Susila Nindya Reza Gunadi Ranuh Andy Darma Khadijah Rizky Sumitro Purwo Sri Rejeki Lilik Djuari Subijanto Marto Sudarmo Rina Agustina Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials Food Hydrocolloids for Health Probiotic Gut permeability Obese Randomized controlled trial Gut microbiota |
| title | Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials |
| title_full | Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials |
| title_fullStr | Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials |
| title_full_unstemmed | Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials |
| title_short | Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials |
| title_sort | role of oral probiotic supplementation on gut permeability in obesity a systematic review of randomized controlled trials |
| topic | Probiotic Gut permeability Obese Randomized controlled trial Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2667025925000317 |
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