Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study
BackgroundThyroid hormone sensitivity indices represent a recently proposed clinical entity related to metabolic health outcomes. The link between thyroid hormone sensitivity and prediabetes is not clear. This population-based study investigated the association between thyroid hormone sensitivity in...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1534058/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850219351915888640 |
|---|---|
| author | Ladan Mehran Mohammadjavad Honarvar Maryam Tohidi Maryam Adib Fereidoun Azizi Atieh Amouzegar |
| author_facet | Ladan Mehran Mohammadjavad Honarvar Maryam Tohidi Maryam Adib Fereidoun Azizi Atieh Amouzegar |
| author_sort | Ladan Mehran |
| collection | DOAJ |
| description | BackgroundThyroid hormone sensitivity indices represent a recently proposed clinical entity related to metabolic health outcomes. The link between thyroid hormone sensitivity and prediabetes is not clear. This population-based study investigated the association between thyroid hormone sensitivity indices and prediabetes.MethodsAmong 5,783 participants over 20 years, after excluding those receiving thyroid medications or corticosteroid drugs, having thyroid surgery, having a history of cancer, pregnant women, and those with end-stage renal disease, 4,356 subjects were included in the study. The odds ratio (OR) and 95% confidence interval (95%CI) for prediabetes in the general and euthyroid population per 1-SD increase in thyroid hormone resistance indices (PFTQI, TSHI, and lnTT4RI) were reported with logistic regression models.ResultsOne SD increase in PTFQI was significantly associated with lower odds of prediabetes even after total adjustment (OR:0.88; 95%CI: 0.82–0.94). The association was observed in women, non-smokers, and those with negative anti-thyroid peroxidase antibodies. In the euthyroid subgroup, one SD increase in PTFQI, TSHI, and lnTT4RI showed lower odds of prediabetes and [PTFQI: 0.89 (95%CI: 0.83–0.97); TSHI: 0.83 (95%CI: 0.74–0.94); lnTT4RI: 0.83 (95%CI: 0.74–0.93)]. We also found a negative correlation between thyroid hormone sensitivity indices and fasting plasma glucose (PTFQI: r =-0.094, TSHI:-0.1, and lnTT4RI: r =-0.098) and 2-h post-challenge glucose (PTFQI: r =-0.096, TSHI:-0.054, and lnTT4RI: r =-0.031).ConclusionLower central sensitivity to thyroid hormone, as represented by increased TSHI, TT4RI, and PTFQI, is associated with a lower risk of prediabetes, even in euthyroid individuals. |
| format | Article |
| id | doaj-art-74bf4c76ecb1498592efda56cb4bdc64 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-74bf4c76ecb1498592efda56cb4bdc642025-08-20T02:07:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15340581534058Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid studyLadan Mehran0Mohammadjavad Honarvar1Maryam Tohidi2Maryam Adib3Fereidoun Azizi4Atieh Amouzegar5Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranBackgroundThyroid hormone sensitivity indices represent a recently proposed clinical entity related to metabolic health outcomes. The link between thyroid hormone sensitivity and prediabetes is not clear. This population-based study investigated the association between thyroid hormone sensitivity indices and prediabetes.MethodsAmong 5,783 participants over 20 years, after excluding those receiving thyroid medications or corticosteroid drugs, having thyroid surgery, having a history of cancer, pregnant women, and those with end-stage renal disease, 4,356 subjects were included in the study. The odds ratio (OR) and 95% confidence interval (95%CI) for prediabetes in the general and euthyroid population per 1-SD increase in thyroid hormone resistance indices (PFTQI, TSHI, and lnTT4RI) were reported with logistic regression models.ResultsOne SD increase in PTFQI was significantly associated with lower odds of prediabetes even after total adjustment (OR:0.88; 95%CI: 0.82–0.94). The association was observed in women, non-smokers, and those with negative anti-thyroid peroxidase antibodies. In the euthyroid subgroup, one SD increase in PTFQI, TSHI, and lnTT4RI showed lower odds of prediabetes and [PTFQI: 0.89 (95%CI: 0.83–0.97); TSHI: 0.83 (95%CI: 0.74–0.94); lnTT4RI: 0.83 (95%CI: 0.74–0.93)]. We also found a negative correlation between thyroid hormone sensitivity indices and fasting plasma glucose (PTFQI: r =-0.094, TSHI:-0.1, and lnTT4RI: r =-0.098) and 2-h post-challenge glucose (PTFQI: r =-0.096, TSHI:-0.054, and lnTT4RI: r =-0.031).ConclusionLower central sensitivity to thyroid hormone, as represented by increased TSHI, TT4RI, and PTFQI, is associated with a lower risk of prediabetes, even in euthyroid individuals.https://www.frontiersin.org/articles/10.3389/fendo.2025.1534058/fullthyroid functionparametric thyroid feedback quantile-based indexthyroid hormone resistanceprediabetesthyroid-stimulating hormone indexthyrotrophic thyroxin resistance index |
| spellingShingle | Ladan Mehran Mohammadjavad Honarvar Maryam Tohidi Maryam Adib Fereidoun Azizi Atieh Amouzegar Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study Frontiers in Endocrinology thyroid function parametric thyroid feedback quantile-based index thyroid hormone resistance prediabetes thyroid-stimulating hormone index thyrotrophic thyroxin resistance index |
| title | Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study |
| title_full | Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study |
| title_fullStr | Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study |
| title_full_unstemmed | Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study |
| title_short | Association between central thyroid hormone sensitivity and prediabetes: Tehran thyroid study |
| title_sort | association between central thyroid hormone sensitivity and prediabetes tehran thyroid study |
| topic | thyroid function parametric thyroid feedback quantile-based index thyroid hormone resistance prediabetes thyroid-stimulating hormone index thyrotrophic thyroxin resistance index |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1534058/full |
| work_keys_str_mv | AT ladanmehran associationbetweencentralthyroidhormonesensitivityandprediabetestehranthyroidstudy AT mohammadjavadhonarvar associationbetweencentralthyroidhormonesensitivityandprediabetestehranthyroidstudy AT maryamtohidi associationbetweencentralthyroidhormonesensitivityandprediabetestehranthyroidstudy AT maryamadib associationbetweencentralthyroidhormonesensitivityandprediabetestehranthyroidstudy AT fereidounazizi associationbetweencentralthyroidhormonesensitivityandprediabetestehranthyroidstudy AT atiehamouzegar associationbetweencentralthyroidhormonesensitivityandprediabetestehranthyroidstudy |