Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study
Abstract Background Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most co...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12903-024-05276-5 |
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| author | Razieh Zare Leila Izadi Mario Alberto Alarcón-Sánchez Masumeh Taghva Mohammad Ali Ranjbar |
| author_facet | Razieh Zare Leila Izadi Mario Alberto Alarcón-Sánchez Masumeh Taghva Mohammad Ali Ranjbar |
| author_sort | Razieh Zare |
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| description | Abstract Background Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and malignant salivary gland tumors by immunohistochemistry. Methods In this retrospective cross-sectional study, 68 cases including 25 pleomorphic adenomas (PAs), 21 adenoid cystic carcinomas (ADCa), 15 mucoepidermoid carcinomas (MEC), and 7 normal salivary glands (NSG) were enrolled from the archive of the Department of Pathology of Shiraz School of Dentistry, Iran. The expression of AurkA in the tissue samples was assessed by immunohistochemical method and was analyzed using statistical analysis (p < 0.05). Results Of total cases analyzed, the majority of benign and malignant tumors were found to involve minor salivary glands compared to major salivary glands (p < 0.001). In addition, all lesions studied expressed AurkA. More than half of the tumor tissues showed AurkA staining percentages between 26 and 50% and 76–100% compared to NSG (p = 0.08). In 44.1% of cases, cells had a weak staining score, 27.9% a moderate score and the rest (27.9%) a strong score (p = 0.64). Conclusion Although AurkA was observed to be expressed in all tumor tissues, further studies are needed to clearly understand the role of AurkA and the possibility of using it as a diagnostic, prognostic and therapeutic factor. |
| format | Article |
| id | doaj-art-74b85168f21047dcba802d5b18092d59 |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Oral Health |
| spelling | doaj-art-74b85168f21047dcba802d5b18092d592025-01-19T12:41:23ZengBMCBMC Oral Health1472-68312025-01-012511810.1186/s12903-024-05276-5Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical studyRazieh Zare0Leila Izadi1Mario Alberto Alarcón-Sánchez2Masumeh Taghva3Mohammad Ali Ranjbar4Department of Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical SciencesUndergraduate Student, School of Dentistry, Shiraz University of Medical SciencesBiomedical Science, Faculty of Chemical-Biological Sciences, Autonomous University of GuerreroDepartment of Prosthodontics, School of Dentistry, Shiraz University of Medical SciencesDepartment of Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical SciencesAbstract Background Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and malignant salivary gland tumors by immunohistochemistry. Methods In this retrospective cross-sectional study, 68 cases including 25 pleomorphic adenomas (PAs), 21 adenoid cystic carcinomas (ADCa), 15 mucoepidermoid carcinomas (MEC), and 7 normal salivary glands (NSG) were enrolled from the archive of the Department of Pathology of Shiraz School of Dentistry, Iran. The expression of AurkA in the tissue samples was assessed by immunohistochemical method and was analyzed using statistical analysis (p < 0.05). Results Of total cases analyzed, the majority of benign and malignant tumors were found to involve minor salivary glands compared to major salivary glands (p < 0.001). In addition, all lesions studied expressed AurkA. More than half of the tumor tissues showed AurkA staining percentages between 26 and 50% and 76–100% compared to NSG (p = 0.08). In 44.1% of cases, cells had a weak staining score, 27.9% a moderate score and the rest (27.9%) a strong score (p = 0.64). Conclusion Although AurkA was observed to be expressed in all tumor tissues, further studies are needed to clearly understand the role of AurkA and the possibility of using it as a diagnostic, prognostic and therapeutic factor.https://doi.org/10.1186/s12903-024-05276-5Aurora kinase AImmunohistochemistryPleomorphic adenomaAdenoid cystic carcinomaMucoepidermoid carcinoma |
| spellingShingle | Razieh Zare Leila Izadi Mario Alberto Alarcón-Sánchez Masumeh Taghva Mohammad Ali Ranjbar Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study BMC Oral Health Aurora kinase A Immunohistochemistry Pleomorphic adenoma Adenoid cystic carcinoma Mucoepidermoid carcinoma |
| title | Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study |
| title_full | Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study |
| title_fullStr | Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study |
| title_full_unstemmed | Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study |
| title_short | Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study |
| title_sort | aurora kinase a expression in pleomorphic adenoma adenoid cystic carcinoma and mucoepidermoid carcinoma of salivary glands an immunohistochemical study |
| topic | Aurora kinase A Immunohistochemistry Pleomorphic adenoma Adenoid cystic carcinoma Mucoepidermoid carcinoma |
| url | https://doi.org/10.1186/s12903-024-05276-5 |
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