Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium.

Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium.

<h4>Background</h4>Follicular structures resembling germinal centres (GCs) that are characterized by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed tissues in autoimmune diseases, including the synovium of rheumatoid arthritis (RA). However, it...

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Main Authors: Frances Humby, Michele Bombardieri, Antonio Manzo, Stephen Kelly, Mark C Blades, Bruce Kirkham, Jo Spencer, Costantino Pitzalis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0060001&type=printable
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