Catalytic asymmetric intermolecular [4 + 2] annulation of benzocyclobutenones with Alkynes and activated carbonyls via C—C activation

Catalytic asymmetric intermolecular [4 + 2] annulation of benzocyclobutenones with Alkynes and activated carbonyls via C—C activation

Abstract The activation of C—C bonds enables rapid construction of new organic frameworks owing to facile structural reorganization. Nevertheless, enantioselective C—C activation remains heavily underexplored and has been predominantly limited to intramolecular reactions. We herein report two catego...

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Bibliographic Details
Main Authors: Huilai Liu, Zisong Qi, Yue Shi, Wei Wang, Fen Wang, Zhi-Wen Ding, Ai-Qun Jia, Genping Huang, Xingwei Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60109-5
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