Investigating blood–brain barrier penetration and neurotoxicity of natural products for central nervous system drug development

Investigating blood–brain barrier penetration and neurotoxicity of natural products for central nervous system drug development

Abstract Natural Products (NPs) are increasingly utilized worldwide for their potential therapeutic benefits, including central nervous system (CNS) disorders. Studies have shown açai berries mitigating Parkinson’s disease progression through dopaminergic neuroprotection via Nrf-2 HO-1 pathways. Ash...

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Bibliographic Details
Main Authors: Rintaro Kato, Li Zhang, Nivedita Kinatukara, Ruili Huang, Abhinav Asthana, Claire Weber, Menghang Xia, Xin Xu, Pranav Shah
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Natural products (NPs)
PAMPA-BBB
CNS drug discovery
Neurotoxicity
Neurite outgrowth assay
Online Access:https://doi.org/10.1038/s41598-025-90888-2
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