Aging-related impairment of neurogenic chloride secretion in human colon mucosa

Aging-related impairment of neurogenic chloride secretion in human colon mucosa

Backgroundlderly individuals are more susceptible to chronic constipation, which may be linked to imbalanced mucosa secretion and absorption. Our research aims to explore the age-related alterations in epithelial chloride secretion within the human colon.MethodsColonic mucosal tissues were obtained...

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Bibliographic Details
Main Authors: Ruiyun Wang, Jing He, Pengcheng Yang, Tao Bai, Jun Song, Xiaohua Hou, Lei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Physiology
Subjects:
aging
intestinal epithelium
chloride secretion
elderly constipation
enteric neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1540465/full
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