Impaired executive functions in experimental model of temporal lobe epilepsy
ABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2016-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600470&lng=en&tlng=en |
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| author | Fabiane Ochai Ramos Luiz Renato Rodrigues Carreiro Fulvio Alexandre Scorza Roberta Monterazzo Cysneiros |
| author_facet | Fabiane Ochai Ramos Luiz Renato Rodrigues Carreiro Fulvio Alexandre Scorza Roberta Monterazzo Cysneiros |
| author_sort | Fabiane Ochai Ramos |
| collection | DOAJ |
| description | ABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior. |
| format | Article |
| id | doaj-art-74b189f828454ee7b25655e48ae0edf1 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-74b189f828454ee7b25655e48ae0edf12025-08-20T01:57:45ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272016-06-0174647047710.1590/0004-282X20160070S0004-282X2016000600470Impaired executive functions in experimental model of temporal lobe epilepsyFabiane Ochai RamosLuiz Renato Rodrigues CarreiroFulvio Alexandre ScorzaRoberta Monterazzo CysneirosABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600470&lng=en&tlng=enepilepsia do lobo temporalfunção executivapilocarpinamemória de curto prazo |
| spellingShingle | Fabiane Ochai Ramos Luiz Renato Rodrigues Carreiro Fulvio Alexandre Scorza Roberta Monterazzo Cysneiros Impaired executive functions in experimental model of temporal lobe epilepsy Arquivos de Neuro-Psiquiatria epilepsia do lobo temporal função executiva pilocarpina memória de curto prazo |
| title | Impaired executive functions in experimental model of temporal lobe epilepsy |
| title_full | Impaired executive functions in experimental model of temporal lobe epilepsy |
| title_fullStr | Impaired executive functions in experimental model of temporal lobe epilepsy |
| title_full_unstemmed | Impaired executive functions in experimental model of temporal lobe epilepsy |
| title_short | Impaired executive functions in experimental model of temporal lobe epilepsy |
| title_sort | impaired executive functions in experimental model of temporal lobe epilepsy |
| topic | epilepsia do lobo temporal função executiva pilocarpina memória de curto prazo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600470&lng=en&tlng=en |
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