An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms
<b>Background:</b> Periodontal disease (PD) is a chronic inflammatory condition associated with dysbiotic biofilm, leading to the destruction of bone and periodontal ligament. Scaling and root planing (SRP) is the gold-standard treatment for PD, but some patients may not respond adequate...
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MDPI AG
2025-04-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/5/2/19 |
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| author | Valdo Antonio Aires da Silva Bruno Bueno-Silva Luciene Cristina Figueiredo Tatiane Tiemi Macedo Lucas Daylor Aguiar da Silva Helio Chagas Chaves de Oliveira Junior Carlos Roberto Polaquini Luís Octávio Regasini Janaina de Cássia Orlandi Sardi |
| author_facet | Valdo Antonio Aires da Silva Bruno Bueno-Silva Luciene Cristina Figueiredo Tatiane Tiemi Macedo Lucas Daylor Aguiar da Silva Helio Chagas Chaves de Oliveira Junior Carlos Roberto Polaquini Luís Octávio Regasini Janaina de Cássia Orlandi Sardi |
| author_sort | Valdo Antonio Aires da Silva |
| collection | DOAJ |
| description | <b>Background:</b> Periodontal disease (PD) is a chronic inflammatory condition associated with dysbiotic biofilm, leading to the destruction of bone and periodontal ligament. Scaling and root planing (SRP) is the gold-standard treatment for PD, but some patients may not respond adequately, necessitating adjunctive therapies. This study investigated the antimicrobial activity of diacetylcurcumin (DAC), a modified curcumin, against multispecies subgingival biofilm associated with periodontitis. <b>Methods:</b> The biofilm, containing 40 bacterial species, was cultured for seven days in the Calgary apparatus. Treatments with DAC (200 μg/mL), 0.12% chlorhexidine (CHX), and a vehicle (control) were applied twice daily for 1 min, starting on the third day. On the seventh day, biofilms were analyzed for metabolic activity (MA) and bacterial counts via DNA-DNA hybridization. DAC toxicity was tested on <i>Galleria mellonella</i> larvae. <b>Results:</b> DAC reduced biofilm metabolic activity by 51%, while CHX achieved 88% reduction compared to the vehicle (<i>p</i> < 0.05). DAC also significantly decreased counts of key periodontal pathogens, including <i>P. gingivalis</i>, <i>T. forsythia</i>, <i>P. intermedia</i>, and <i>A. actinomycetemcomitans</i> (<i>p</i> < 0.05). At the tested concentration, DAC showed no toxicity in larvae. <b>Conclusions:</b> These findings suggest that DAC effectively reduces biofilm activity and periodontal pathogen counts, presenting a promising adjunctive therapy for PD. |
| format | Article |
| id | doaj-art-74afad7b542d4608b469a005c85dbef4 |
| institution | Kabale University |
| issn | 2673-9879 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj-art-74afad7b542d4608b469a005c85dbef42025-08-20T03:24:38ZengMDPI AGFuture Pharmacology2673-98792025-04-01521910.3390/futurepharmacol5020019An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival BiofilmsValdo Antonio Aires da Silva0Bruno Bueno-Silva1Luciene Cristina Figueiredo2Tatiane Tiemi Macedo3Lucas Daylor Aguiar da Silva4Helio Chagas Chaves de Oliveira Junior5Carlos Roberto Polaquini6Luís Octávio Regasini7Janaina de Cássia Orlandi Sardi8Dental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, BrazilDepartment of Chemistry and Environmental Sciences, Júlio de Mesquita Filho University, São Jose do Rio Preto 15054-000, SP, BrazilDepartment of Chemistry and Environmental Sciences, Júlio de Mesquita Filho University, São Jose do Rio Preto 15054-000, SP, BrazilDental Research Division, Guarulhos University, Guarulhos 07023-070, SP, Brazil<b>Background:</b> Periodontal disease (PD) is a chronic inflammatory condition associated with dysbiotic biofilm, leading to the destruction of bone and periodontal ligament. Scaling and root planing (SRP) is the gold-standard treatment for PD, but some patients may not respond adequately, necessitating adjunctive therapies. This study investigated the antimicrobial activity of diacetylcurcumin (DAC), a modified curcumin, against multispecies subgingival biofilm associated with periodontitis. <b>Methods:</b> The biofilm, containing 40 bacterial species, was cultured for seven days in the Calgary apparatus. Treatments with DAC (200 μg/mL), 0.12% chlorhexidine (CHX), and a vehicle (control) were applied twice daily for 1 min, starting on the third day. On the seventh day, biofilms were analyzed for metabolic activity (MA) and bacterial counts via DNA-DNA hybridization. DAC toxicity was tested on <i>Galleria mellonella</i> larvae. <b>Results:</b> DAC reduced biofilm metabolic activity by 51%, while CHX achieved 88% reduction compared to the vehicle (<i>p</i> < 0.05). DAC also significantly decreased counts of key periodontal pathogens, including <i>P. gingivalis</i>, <i>T. forsythia</i>, <i>P. intermedia</i>, and <i>A. actinomycetemcomitans</i> (<i>p</i> < 0.05). At the tested concentration, DAC showed no toxicity in larvae. <b>Conclusions:</b> These findings suggest that DAC effectively reduces biofilm activity and periodontal pathogen counts, presenting a promising adjunctive therapy for PD.https://www.mdpi.com/2673-9879/5/2/19DACbiofilmperiodontitistoxicity<i>Galleria mellonella</i> |
| spellingShingle | Valdo Antonio Aires da Silva Bruno Bueno-Silva Luciene Cristina Figueiredo Tatiane Tiemi Macedo Lucas Daylor Aguiar da Silva Helio Chagas Chaves de Oliveira Junior Carlos Roberto Polaquini Luís Octávio Regasini Janaina de Cássia Orlandi Sardi An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms Future Pharmacology DAC biofilm periodontitis toxicity <i>Galleria mellonella</i> |
| title | An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms |
| title_full | An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms |
| title_fullStr | An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms |
| title_full_unstemmed | An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms |
| title_short | An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms |
| title_sort | in vitro diacetylcurcumin study for periodontitis a new approach to controlling subgingival biofilms |
| topic | DAC biofilm periodontitis toxicity <i>Galleria mellonella</i> |
| url | https://www.mdpi.com/2673-9879/5/2/19 |
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