Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration
Photocatalysis and photodynamic therapy have been increasingly used in the management of diabetic foot ulcers (DFUs), and their integration into increasingly innovative treatment protocols enables effective infection control. Advanced techniques such as antibacterial photodynamic therapy (aPDT), lip...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/11/2323 |
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| author | Paweł Mikziński Karolina Kraus Rafał Seredyński Jarosław Widelski Emil Paluch |
| author_facet | Paweł Mikziński Karolina Kraus Rafał Seredyński Jarosław Widelski Emil Paluch |
| author_sort | Paweł Mikziński |
| collection | DOAJ |
| description | Photocatalysis and photodynamic therapy have been increasingly used in the management of diabetic foot ulcers (DFUs), and their integration into increasingly innovative treatment protocols enables effective infection control. Advanced techniques such as antibacterial photodynamic therapy (aPDT), liposomal photocatalytic carriers, nanoparticles, and nanomotors—used alone, in combination, or with the addition of antibiotics, lysozyme, or phage enzymes—offer promising solutions for wound treatment. These approaches are particularly effective even in the presence of comorbidities such as angiopathies, neuropathies, and immune system disorders, which are common among diabetic patients. Notably, the use of combination therapies holds great potential for addressing challenges within diabetic foot ulcers, including hypoxia, poor circulation, high glucose levels, increased oxidative stress, and rapid biofilm formation—factors that significantly hinder wound healing in diabetic patients. The integration of modern therapeutic strategies is essential for effective clinical practice, starting with halting infection progression, ensuring its effective eradication, and promoting proper tissue regeneration, especially considering that, according to the WHO, 830 million people worldwide suffer from diabetes. |
| format | Article |
| id | doaj-art-74ab0735454f4f7d90d546c8ca74f50d |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-74ab0735454f4f7d90d546c8ca74f50d2025-08-20T03:46:42ZengMDPI AGMolecules1420-30492025-05-013011232310.3390/molecules30112323Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue RegenerationPaweł Mikziński0Karolina Kraus1Rafał Seredyński2Jarosław Widelski3Emil Paluch4Faculty of Medicine, Wroclaw Medical University, Wyb. Pasteura 1, 50-376 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Wyb. Pasteura 1, 50-376 Wroclaw, PolandDepartment of Physiology and Pathophysiology, Wroclaw Medical University, Tytusa Chałubińskiego 10, 50-368 Wroclaw, PolandDepartment of Pharmacognosy with Medicinal Plants Garden, Lublin Medical University, 20-093 Lublin, PolandDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Tytusa Chalubinskiego 4, 50-376 Wroclaw, PolandPhotocatalysis and photodynamic therapy have been increasingly used in the management of diabetic foot ulcers (DFUs), and their integration into increasingly innovative treatment protocols enables effective infection control. Advanced techniques such as antibacterial photodynamic therapy (aPDT), liposomal photocatalytic carriers, nanoparticles, and nanomotors—used alone, in combination, or with the addition of antibiotics, lysozyme, or phage enzymes—offer promising solutions for wound treatment. These approaches are particularly effective even in the presence of comorbidities such as angiopathies, neuropathies, and immune system disorders, which are common among diabetic patients. Notably, the use of combination therapies holds great potential for addressing challenges within diabetic foot ulcers, including hypoxia, poor circulation, high glucose levels, increased oxidative stress, and rapid biofilm formation—factors that significantly hinder wound healing in diabetic patients. The integration of modern therapeutic strategies is essential for effective clinical practice, starting with halting infection progression, ensuring its effective eradication, and promoting proper tissue regeneration, especially considering that, according to the WHO, 830 million people worldwide suffer from diabetes.https://www.mdpi.com/1420-3049/30/11/2323diabetic foot ulcersdiabetic woundphotocatalysisphotosensitizertissue regenerationantibacterial photodynamic therapy |
| spellingShingle | Paweł Mikziński Karolina Kraus Rafał Seredyński Jarosław Widelski Emil Paluch Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration Molecules diabetic foot ulcers diabetic wound photocatalysis photosensitizer tissue regeneration antibacterial photodynamic therapy |
| title | Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration |
| title_full | Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration |
| title_fullStr | Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration |
| title_full_unstemmed | Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration |
| title_short | Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration |
| title_sort | photocatalysis and photodynamic therapy in diabetic foot ulcers dfus care a novel approach to infection control and tissue regeneration |
| topic | diabetic foot ulcers diabetic wound photocatalysis photosensitizer tissue regeneration antibacterial photodynamic therapy |
| url | https://www.mdpi.com/1420-3049/30/11/2323 |
| work_keys_str_mv | AT pawełmikzinski photocatalysisandphotodynamictherapyindiabeticfootulcersdfuscareanovelapproachtoinfectioncontrolandtissueregeneration AT karolinakraus photocatalysisandphotodynamictherapyindiabeticfootulcersdfuscareanovelapproachtoinfectioncontrolandtissueregeneration AT rafałseredynski photocatalysisandphotodynamictherapyindiabeticfootulcersdfuscareanovelapproachtoinfectioncontrolandtissueregeneration AT jarosławwidelski photocatalysisandphotodynamictherapyindiabeticfootulcersdfuscareanovelapproachtoinfectioncontrolandtissueregeneration AT emilpaluch photocatalysisandphotodynamictherapyindiabeticfootulcersdfuscareanovelapproachtoinfectioncontrolandtissueregeneration |