The cGAS-STING pathway in atherosclerosis
Atherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression. This pathway is activated by cytoplasmi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1550930/full |
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| author | Si-yu Wang Si-yu Wang Si-yu Wang Yu-shan Chen Yu-shan Chen Bo-yuan Jin Bo-yuan Jin Bo-yuan Jin Ahmad Bilal Ahmad Bilal Ahmad Bilal |
| author_facet | Si-yu Wang Si-yu Wang Si-yu Wang Yu-shan Chen Yu-shan Chen Bo-yuan Jin Bo-yuan Jin Bo-yuan Jin Ahmad Bilal Ahmad Bilal Ahmad Bilal |
| author_sort | Si-yu Wang |
| collection | DOAJ |
| description | Atherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression. This pathway is activated by cytoplasmic DNA from damaged cells, thereby triggering inflammation and accelerating plaque formation. While risk factors such as aging, obesity, smoking, hypertension, and diabetes are known to exacerbate AS, emerging evidence suggests that these factors may also enhance cGAS-STING pathway, which amplifies inflammatory responses. Targeting this pathway offers a promising therapeutic strategy to reduce the burden of cardiovascular diseases (CVD). In this review, we summarize the mechanisms of the cGAS-STING pathway, explore its role in AS, and evaluate potential inhibitors as future therapeutic candidates. By integrating current knowledge, we aim to provide insights for developing novel treatments to mitigate AS and CVD burden. |
| format | Article |
| id | doaj-art-74a6087dbfc642cfb7daf0d7c70ae9cf |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-74a6087dbfc642cfb7daf0d7c70ae9cf2025-08-20T03:31:27ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-04-011210.3389/fcvm.2025.15509301550930The cGAS-STING pathway in atherosclerosisSi-yu Wang0Si-yu Wang1Si-yu Wang2Yu-shan Chen3Yu-shan Chen4Bo-yuan Jin5Bo-yuan Jin6Bo-yuan Jin7Ahmad Bilal8Ahmad Bilal9Ahmad Bilal10Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaDepartment of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaThe First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaHeart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaDepartment of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaHeart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaDepartment of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaThe First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaHeart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaDepartment of Cardiology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaThe First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, ChinaAtherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression. This pathway is activated by cytoplasmic DNA from damaged cells, thereby triggering inflammation and accelerating plaque formation. While risk factors such as aging, obesity, smoking, hypertension, and diabetes are known to exacerbate AS, emerging evidence suggests that these factors may also enhance cGAS-STING pathway, which amplifies inflammatory responses. Targeting this pathway offers a promising therapeutic strategy to reduce the burden of cardiovascular diseases (CVD). In this review, we summarize the mechanisms of the cGAS-STING pathway, explore its role in AS, and evaluate potential inhibitors as future therapeutic candidates. By integrating current knowledge, we aim to provide insights for developing novel treatments to mitigate AS and CVD burden.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1550930/fullatherosclerosiscGAS-STING pathwayrisk factorstherapeutic potentialcGAS inhibitorsSTING inhibitors |
| spellingShingle | Si-yu Wang Si-yu Wang Si-yu Wang Yu-shan Chen Yu-shan Chen Bo-yuan Jin Bo-yuan Jin Bo-yuan Jin Ahmad Bilal Ahmad Bilal Ahmad Bilal The cGAS-STING pathway in atherosclerosis Frontiers in Cardiovascular Medicine atherosclerosis cGAS-STING pathway risk factors therapeutic potential cGAS inhibitors STING inhibitors |
| title | The cGAS-STING pathway in atherosclerosis |
| title_full | The cGAS-STING pathway in atherosclerosis |
| title_fullStr | The cGAS-STING pathway in atherosclerosis |
| title_full_unstemmed | The cGAS-STING pathway in atherosclerosis |
| title_short | The cGAS-STING pathway in atherosclerosis |
| title_sort | cgas sting pathway in atherosclerosis |
| topic | atherosclerosis cGAS-STING pathway risk factors therapeutic potential cGAS inhibitors STING inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1550930/full |
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