Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis
<b>Objective:</b> This study aimed to investigate the etiology, pathogens, antibiotic susceptibility, treatments, and factors influencing the visual prognosis of pediatric post-traumatic endophthalmitis (PTE) to provide valuable insights for clinical diagnosis and treatment. <b>Res...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/14/1/20 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589334834839552 |
|---|---|
| author | Xiaoxia Li Yibin Zhou Zhi Chen Xiuwen Zhang Zimei Zhou Maureen Boost Taomin Huang Xingtao Zhou |
| author_facet | Xiaoxia Li Yibin Zhou Zhi Chen Xiuwen Zhang Zimei Zhou Maureen Boost Taomin Huang Xingtao Zhou |
| author_sort | Xiaoxia Li |
| collection | DOAJ |
| description | <b>Objective:</b> This study aimed to investigate the etiology, pathogens, antibiotic susceptibility, treatments, and factors influencing the visual prognosis of pediatric post-traumatic endophthalmitis (PTE) to provide valuable insights for clinical diagnosis and treatment. <b>Results:</b> A total of 301 children were included, with 142 (47.2%) cultures yielding positive results. Gram-positive cocci were the predominant pathogens (71.1%), with high sensitivity to vancomycin (95.4%). Pars plana vitrectomy (PPV) was performed in 216 eyes (71.8%), with emergency or immediate vitrectomy within 24 h of hospitalization performed on 171 eyes (56.8%). The first intravitreal antibiotic injection, consisting of ceftazidime and norvancomycin, was administered to 248 patients (82.4%). The absence of retinal detachment (OR, 0.191; 95% CI, 0.065–0.560; <i>p</i> = 0.002), normal intraocular pressure (OR, 1.894; 95% CI, 1.151–3.117; <i>p</i> = 0.012), and no lens extraction (OR, 0.187; 95% CI, 0.069–0.504; <i>p</i> < 0.001) were found to be independent factors associated with better visual outcomes (BCVA) in pediatric PTE patients. <b>Methods:</b> A retrospective analysis was conducted on pediatric PTE patients treated between January 2012 and June 2022. Data were collected on clinical characteristics, causative pathogens, antibiotic sensitivity, treatments, and visual outcomes. <b>Conclusions:</b> Gram-positive cocci are the most common pathogens in pediatric PTE, with early vitrectomy and intravitreal ceftazidime and norvancomycin being the most effective treatments. Favorable visual outcomes are strongly associated with the absence of retinal detachment, normal intraocular pressure, and no lens extraction. These findings highlight the need for timely surgical and antimicrobial interventions tailored to each patient to improve visual prognosis. |
| format | Article |
| id | doaj-art-74a533652305474b8bfcc15537d46977 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-74a533652305474b8bfcc15537d469772025-01-24T13:18:34ZengMDPI AGAntibiotics2079-63822025-01-011412010.3390/antibiotics14010020Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic EndophthalmitisXiaoxia Li0Yibin Zhou1Zhi Chen2Xiuwen Zhang3Zimei Zhou4Maureen Boost5Taomin Huang6Xingtao Zhou7Department of Pharmacy, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Pharmacy, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Pharmacy, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology, BronxCare Health System, Bronx, NY 10456, USASchool of Optometry, Hong Kong Polytechnic University, Hong Kong SAR 999077, ChinaDepartment of Pharmacy, Eye & ENT Hospital, Fudan University, Shanghai 200031, ChinaEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China<b>Objective:</b> This study aimed to investigate the etiology, pathogens, antibiotic susceptibility, treatments, and factors influencing the visual prognosis of pediatric post-traumatic endophthalmitis (PTE) to provide valuable insights for clinical diagnosis and treatment. <b>Results:</b> A total of 301 children were included, with 142 (47.2%) cultures yielding positive results. Gram-positive cocci were the predominant pathogens (71.1%), with high sensitivity to vancomycin (95.4%). Pars plana vitrectomy (PPV) was performed in 216 eyes (71.8%), with emergency or immediate vitrectomy within 24 h of hospitalization performed on 171 eyes (56.8%). The first intravitreal antibiotic injection, consisting of ceftazidime and norvancomycin, was administered to 248 patients (82.4%). The absence of retinal detachment (OR, 0.191; 95% CI, 0.065–0.560; <i>p</i> = 0.002), normal intraocular pressure (OR, 1.894; 95% CI, 1.151–3.117; <i>p</i> = 0.012), and no lens extraction (OR, 0.187; 95% CI, 0.069–0.504; <i>p</i> < 0.001) were found to be independent factors associated with better visual outcomes (BCVA) in pediatric PTE patients. <b>Methods:</b> A retrospective analysis was conducted on pediatric PTE patients treated between January 2012 and June 2022. Data were collected on clinical characteristics, causative pathogens, antibiotic sensitivity, treatments, and visual outcomes. <b>Conclusions:</b> Gram-positive cocci are the most common pathogens in pediatric PTE, with early vitrectomy and intravitreal ceftazidime and norvancomycin being the most effective treatments. Favorable visual outcomes are strongly associated with the absence of retinal detachment, normal intraocular pressure, and no lens extraction. These findings highlight the need for timely surgical and antimicrobial interventions tailored to each patient to improve visual prognosis.https://www.mdpi.com/2079-6382/14/1/20pediatric post-traumatic endophthalmitispars plana vitrectomy (PPV)best-corrected visual acuity (BCVA)retinal detachmentnorvancomycin |
| spellingShingle | Xiaoxia Li Yibin Zhou Zhi Chen Xiuwen Zhang Zimei Zhou Maureen Boost Taomin Huang Xingtao Zhou Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis Antibiotics pediatric post-traumatic endophthalmitis pars plana vitrectomy (PPV) best-corrected visual acuity (BCVA) retinal detachment norvancomycin |
| title | Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis |
| title_full | Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis |
| title_fullStr | Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis |
| title_full_unstemmed | Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis |
| title_short | Clinical Characteristics, Pathogen Distribution, and Factors Affecting Visual Outcomes of Pediatric Post-Traumatic Endophthalmitis |
| title_sort | clinical characteristics pathogen distribution and factors affecting visual outcomes of pediatric post traumatic endophthalmitis |
| topic | pediatric post-traumatic endophthalmitis pars plana vitrectomy (PPV) best-corrected visual acuity (BCVA) retinal detachment norvancomycin |
| url | https://www.mdpi.com/2079-6382/14/1/20 |
| work_keys_str_mv | AT xiaoxiali clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT yibinzhou clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT zhichen clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT xiuwenzhang clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT zimeizhou clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT maureenboost clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT taominhuang clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis AT xingtaozhou clinicalcharacteristicspathogendistributionandfactorsaffectingvisualoutcomesofpediatricposttraumaticendophthalmitis |