Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population
Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated inflammation. Single nucleotide polymorphisms in TRPA1...
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Elsevier
2025-10-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325002177 |
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| author | Cong Wang Guifei Deng Siyu Niu Xianglong Meng |
| author_facet | Cong Wang Guifei Deng Siyu Niu Xianglong Meng |
| author_sort | Cong Wang |
| collection | DOAJ |
| description | Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated inflammation. Single nucleotide polymorphisms in TRPA1 and NF-κB1 genes may be associated with individual heterogeneous nephrotoxicity. Materials and methods: In this paper, we investigated the association of 17 single nucleotide polymorphisms (SNP) of TRPA1 and NF-κB1 genes with cisplatin-induced acute nephrotoxicity. Nephrotoxicity and its severity were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE 5.0). SNPs were measured by 48-Plex SNPscan® high-throughput SNP typing echnology in DNA isolated from peripheral blood of 589 Chinese Han lung cancer patients (241 with CIN and 348 without CIN) treated with cisplatin regimen. Results: TRAP1 gene rs920829 locus T allele carriers had a reduced risk of nephrotoxicity relative to C allele carriers (OR 0.684, 95 % CI 0.524–0.894, p = 0.003), and their additive and dominant models showed similar trends as well. However, the SNPs of NF-κB1 were not observed to be correlated with nephrotoxicity. Conclusion: SNPs of TRPA1 have the potential as biomarkers for predicting cisplatin nephrotoxicity. |
| format | Article |
| id | doaj-art-7498cdb4096e4148a75cb8f848877475 |
| institution | DOAJ |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-7498cdb4096e4148a75cb8f8488774752025-08-20T02:58:27ZengElsevierTranslational Oncology1936-52332025-10-016010248610.1016/j.tranon.2025.102486Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese populationCong Wang0Guifei Deng1Siyu Niu2Xianglong Meng3Department of Nephrology, Yibin Traditional Chinese Medicine Hospital. Yibin, Sichuan 644600, ChinaDepartment of Nephrology, Yibin Traditional Chinese Medicine Hospital. Yibin, Sichuan 644600, ChinaDepartment of Anesthesia, Jinniu Hospital of Sichuan Provincial People’s Hospital and Chengdu Jinniu District People’s Hospital. Chengdu, Sichuan 610036, ChinaDepartment of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China; Corresponding author at: Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital University of Electronic Science and Technology of China, No. 32, Section 2, West 1st Ring Road, Qingyang District, Chengdu, Sichuan 610072, China.Introduction: Irreversible acute kidney injury (AKI) caused by cisplatin limits its clinical use, and transient receptor potential anchor protein 1 (TRPA1) regulates cisplatin-induced nephrotoxicity (CIN) through NF-κB signaling pathway-mediated inflammation. Single nucleotide polymorphisms in TRPA1 and NF-κB1 genes may be associated with individual heterogeneous nephrotoxicity. Materials and methods: In this paper, we investigated the association of 17 single nucleotide polymorphisms (SNP) of TRPA1 and NF-κB1 genes with cisplatin-induced acute nephrotoxicity. Nephrotoxicity and its severity were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE 5.0). SNPs were measured by 48-Plex SNPscan® high-throughput SNP typing echnology in DNA isolated from peripheral blood of 589 Chinese Han lung cancer patients (241 with CIN and 348 without CIN) treated with cisplatin regimen. Results: TRAP1 gene rs920829 locus T allele carriers had a reduced risk of nephrotoxicity relative to C allele carriers (OR 0.684, 95 % CI 0.524–0.894, p = 0.003), and their additive and dominant models showed similar trends as well. However, the SNPs of NF-κB1 were not observed to be correlated with nephrotoxicity. Conclusion: SNPs of TRPA1 have the potential as biomarkers for predicting cisplatin nephrotoxicity.http://www.sciencedirect.com/science/article/pii/S1936523325002177Cisplatin nephrotoxicityGenetic polymorphismsTransient receptor potential ankyrin-1Chinese population |
| spellingShingle | Cong Wang Guifei Deng Siyu Niu Xianglong Meng Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population Translational Oncology Cisplatin nephrotoxicity Genetic polymorphisms Transient receptor potential ankyrin-1 Chinese population |
| title | Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population |
| title_full | Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population |
| title_fullStr | Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population |
| title_full_unstemmed | Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population |
| title_short | Genetic polymorphisms of TRPA1 does affect risk of cisplatin induced nephrotoxicity in Chinese population |
| title_sort | genetic polymorphisms of trpa1 does affect risk of cisplatin induced nephrotoxicity in chinese population |
| topic | Cisplatin nephrotoxicity Genetic polymorphisms Transient receptor potential ankyrin-1 Chinese population |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325002177 |
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