The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer
The study objective: to assess the diagnostic value of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the fine needle aspiration (FNA) for the detection of well-differentiated thyroid cancer regional metastases.Material and Methods. The study included 64 patients with well...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2023-05-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2523 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849341306836353024 |
|---|---|
| author | E. Kh. Gogieva I. S. Romanov E. E. Stanyakina S. N. Berdnikov E. L. Pimenova A. I. Umarova |
| author_facet | E. Kh. Gogieva I. S. Romanov E. E. Stanyakina S. N. Berdnikov E. L. Pimenova A. I. Umarova |
| author_sort | E. Kh. Gogieva |
| collection | DOAJ |
| description | The study objective: to assess the diagnostic value of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the fine needle aspiration (FNA) for the detection of well-differentiated thyroid cancer regional metastases.Material and Methods. The study included 64 patients with well-differentiated thyroid cancer. Ultrasound examination revealed 71 enlarged regional lymph nodes. The patients underwent simultaneous FNA cytology examination of lymph nodes and the study of Tg concentration in the washout fluid of the needle aspiration. Regional lymph node metastases were verified in 38 patients. These patients underwent surgery. Histological examination of surgical specimens was performed in 43 out of 71 cases.Results. The sensitivity, specificity, and accuracy of the FNA biopsy and the study of the concentration of thyroglobulin in the in the washout fluid of FNA were 88.5 %, 56.3 %, 76.2 % and 100 %, respectively. The rate of false-positive results of thyroid FNA biopsy was 16 %. The optimal cutoff value for FNA-Tg measurement was 4 g/ml. This made it possible to increase the sensitivity and specificity of the method to 100 %. It was found that the presence of circulating antibodies to Tg in the blood serum had no effect on the diagnostic value of FNA-Tg measurement (p=0.421). There were no statistically significant differences in the levels of thyroglobulin in the in the washout fluid of FNA between patients with Tg concentration above and below the cutoff values (3.9 [0.47; 39.9] ng/ ml vs 12.3 [0.57; 294.8] ng/ml). |
| format | Article |
| id | doaj-art-748c47b980994e4e9d3f40f3fcebbd50 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-748c47b980994e4e9d3f40f3fcebbd502025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-05-0122251310.21294/1814-4861-2023-22-2-5-131099The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancerE. Kh. Gogieva0I. S. Romanov1E. E. Stanyakina2S. N. Berdnikov3E. L. Pimenova4A. I. Umarova5N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the RussiaThe study objective: to assess the diagnostic value of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the fine needle aspiration (FNA) for the detection of well-differentiated thyroid cancer regional metastases.Material and Methods. The study included 64 patients with well-differentiated thyroid cancer. Ultrasound examination revealed 71 enlarged regional lymph nodes. The patients underwent simultaneous FNA cytology examination of lymph nodes and the study of Tg concentration in the washout fluid of the needle aspiration. Regional lymph node metastases were verified in 38 patients. These patients underwent surgery. Histological examination of surgical specimens was performed in 43 out of 71 cases.Results. The sensitivity, specificity, and accuracy of the FNA biopsy and the study of the concentration of thyroglobulin in the in the washout fluid of FNA were 88.5 %, 56.3 %, 76.2 % and 100 %, respectively. The rate of false-positive results of thyroid FNA biopsy was 16 %. The optimal cutoff value for FNA-Tg measurement was 4 g/ml. This made it possible to increase the sensitivity and specificity of the method to 100 %. It was found that the presence of circulating antibodies to Tg in the blood serum had no effect on the diagnostic value of FNA-Tg measurement (p=0.421). There were no statistically significant differences in the levels of thyroglobulin in the in the washout fluid of FNA between patients with Tg concentration above and below the cutoff values (3.9 [0.47; 39.9] ng/ ml vs 12.3 [0.57; 294.8] ng/ml).https://www.siboncoj.ru/jour/article/view/2523thyroglobulin measurement in needle washouts of fine-needle aspiration biopsyfine-needle aspiration biopsyhighly differentiated thyroid cancer |
| spellingShingle | E. Kh. Gogieva I. S. Romanov E. E. Stanyakina S. N. Berdnikov E. L. Pimenova A. I. Umarova The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer Сибирский онкологический журнал thyroglobulin measurement in needle washouts of fine-needle aspiration biopsy fine-needle aspiration biopsy highly differentiated thyroid cancer |
| title | The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer |
| title_full | The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer |
| title_fullStr | The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer |
| title_full_unstemmed | The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer |
| title_short | The role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well-differentiated thyroid cancer |
| title_sort | role of the study of the level of thyroglobulin in the washout fuid of the needle aspiration for the detection of cervical lymph node metastases in well differentiated thyroid cancer |
| topic | thyroglobulin measurement in needle washouts of fine-needle aspiration biopsy fine-needle aspiration biopsy highly differentiated thyroid cancer |
| url | https://www.siboncoj.ru/jour/article/view/2523 |
| work_keys_str_mv | AT ekhgogieva theroleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT isromanov theroleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT eestanyakina theroleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT snberdnikov theroleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT elpimenova theroleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT aiumarova theroleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT ekhgogieva roleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT isromanov roleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT eestanyakina roleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT snberdnikov roleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT elpimenova roleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer AT aiumarova roleofthestudyofthelevelofthyroglobulininthewashoutfuidoftheneedleaspirationforthedetectionofcervicallymphnodemetastasesinwelldifferentiatedthyroidcancer |