Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute
Objective: Gastric neuroendocrine neoplasms (G-NENs) are rare tumors categorized into subtypes, each exhibiting unique characteristics, levels of aggressiveness and prognostic implications. This study aimed to describe the experience on G-NEN management at the Brazilian National Cancer Institute. Me...
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Bioscientifica
2025-03-01
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| Series: | Endocrine Oncology |
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| Online Access: | https://eo.bioscientifica.com/view/journals/eo/5/1/EO-24-0063.xml |
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| author | Sarah Adelaide M Campos Bruno Vilhena Pereira Cibele Barbosa Carroll Rinaldo Gonçalves Reinaldo Rondinelli Daniel Bulzico |
| author_facet | Sarah Adelaide M Campos Bruno Vilhena Pereira Cibele Barbosa Carroll Rinaldo Gonçalves Reinaldo Rondinelli Daniel Bulzico |
| author_sort | Sarah Adelaide M Campos |
| collection | DOAJ |
| description | Objective: Gastric neuroendocrine neoplasms (G-NENs) are rare tumors categorized into subtypes, each exhibiting unique characteristics, levels of aggressiveness and prognostic implications. This study aimed to describe the experience on G-NEN management at the Brazilian National Cancer Institute. Methods: Retrospective analysis involving all patients diagnosed with G-NEN from July 2000 to October 2022. Results: 116 patients with G-NEN were identified; histopathological classification was possible in only 97 patients. Of these, 85 (87.6%) cases were of gastric neuroendocrine tumors (G-NETs) and 12 (12.4%) cases were of gastric neuroendocrine carcinoma (NEC). According to the WHO classification, 51 were classified as NET-G1, 31 as NET-G2, three as NET-G3 and 12 as NEC. Among the G-NETs, type 1 was most prevalent with 60 cases, followed by type 3 (eleven cases) and type 2 (five cases). Nonmetastatic patients were initially treated with endoscopic resection (59 patients), endoscopic surveillance (18 patients) and upfront surgical intervention (18 patients). For metastatic cases, treatment regimens included platinum-based chemotherapy, somatostatin analogs, peptide receptor radionuclide therapy and palliative surgical options. The median overall survival was 84.5 months for NET-G1, 73.4 months for NET-G2, 17.4 months for NET-G3 and 6.2 months for NEC. Conclusion: This report presents the largest cohort of G-NEN in Brazil. While type 1 small G-NET generally exhibits indolent behavior, NEC is characterized by extreme aggressiveness. The survival outcomes observed in this treated population align with those reported in oncology centers from higher-income regions. This underscores the necessity for establishing reference centers dedicated to neuroendocrine tumors in low- to middle-income countries. |
| format | Article |
| id | doaj-art-74893cec748e42bbafb4e631ec6d6bdb |
| institution | OA Journals |
| issn | 2634-4793 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Oncology |
| spelling | doaj-art-74893cec748e42bbafb4e631ec6d6bdb2025-08-20T02:04:54ZengBioscientificaEndocrine Oncology2634-47932025-03-015110.1530/EO-24-00631Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer InstituteSarah Adelaide M Campos0Bruno Vilhena Pereira1Cibele Barbosa Carroll2Rinaldo Gonçalves3Reinaldo Rondinelli4Daniel Bulzico5Clinical Oncology Section, Brazilian National Cancer Institute – INCA, Rio de Janeiro, BrazilClinical Oncology Section, Brazilian National Cancer Institute – INCA, Rio de Janeiro, BrazilCarbone Cancer Center, University of Wisconsin-Madison, Wisconsin, USAAbdominopelvic Surgical Oncology Section, Brazilian National Cancer Institute – INCA, Rio de Janeiro, BrazilAbdominopelvic Surgical Oncology Section, Brazilian National Cancer Institute – INCA, Rio de Janeiro, BrazilNuclear Medicine Section, Brazilian National Cancer Institute – INCA, Rio de Janeiro, BrazilObjective: Gastric neuroendocrine neoplasms (G-NENs) are rare tumors categorized into subtypes, each exhibiting unique characteristics, levels of aggressiveness and prognostic implications. This study aimed to describe the experience on G-NEN management at the Brazilian National Cancer Institute. Methods: Retrospective analysis involving all patients diagnosed with G-NEN from July 2000 to October 2022. Results: 116 patients with G-NEN were identified; histopathological classification was possible in only 97 patients. Of these, 85 (87.6%) cases were of gastric neuroendocrine tumors (G-NETs) and 12 (12.4%) cases were of gastric neuroendocrine carcinoma (NEC). According to the WHO classification, 51 were classified as NET-G1, 31 as NET-G2, three as NET-G3 and 12 as NEC. Among the G-NETs, type 1 was most prevalent with 60 cases, followed by type 3 (eleven cases) and type 2 (five cases). Nonmetastatic patients were initially treated with endoscopic resection (59 patients), endoscopic surveillance (18 patients) and upfront surgical intervention (18 patients). For metastatic cases, treatment regimens included platinum-based chemotherapy, somatostatin analogs, peptide receptor radionuclide therapy and palliative surgical options. The median overall survival was 84.5 months for NET-G1, 73.4 months for NET-G2, 17.4 months for NET-G3 and 6.2 months for NEC. Conclusion: This report presents the largest cohort of G-NEN in Brazil. While type 1 small G-NET generally exhibits indolent behavior, NEC is characterized by extreme aggressiveness. The survival outcomes observed in this treated population align with those reported in oncology centers from higher-income regions. This underscores the necessity for establishing reference centers dedicated to neuroendocrine tumors in low- to middle-income countries.https://eo.bioscientifica.com/view/journals/eo/5/1/EO-24-0063.xmlneuroendocrine tumorgastric neuroendocrine neoplasmgastrintherapysurvival |
| spellingShingle | Sarah Adelaide M Campos Bruno Vilhena Pereira Cibele Barbosa Carroll Rinaldo Gonçalves Reinaldo Rondinelli Daniel Bulzico Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute Endocrine Oncology neuroendocrine tumor gastric neuroendocrine neoplasm gastrin therapy survival |
| title | Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute |
| title_full | Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute |
| title_fullStr | Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute |
| title_full_unstemmed | Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute |
| title_short | Gastric neuroendocrine neoplasms: analysis of a cohort of patients followed at the Brazilian National Cancer Institute |
| title_sort | gastric neuroendocrine neoplasms analysis of a cohort of patients followed at the brazilian national cancer institute |
| topic | neuroendocrine tumor gastric neuroendocrine neoplasm gastrin therapy survival |
| url | https://eo.bioscientifica.com/view/journals/eo/5/1/EO-24-0063.xml |
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