Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study
Abstract Background Endometriosis, characterized as an inflammatory ailment, affects females during their reproductive years, leading to decreased quality of life. Despite the pivotal role of diet as a modifiable risk factor for various chronic conditions, its potential influence on endometriosis ha...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-025-03805-0 |
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| author | Seyed Mojtaba Ghoreishy Fatemeh Sadat Hashemi Javaheri Sakine Ghasemisedaghat Morvarid Noormohammadi Ghazaleh Eslamian Seyyedeh Neda Kazemi Bahram Rashidkhani Robabeh Taheripanah |
| author_facet | Seyed Mojtaba Ghoreishy Fatemeh Sadat Hashemi Javaheri Sakine Ghasemisedaghat Morvarid Noormohammadi Ghazaleh Eslamian Seyyedeh Neda Kazemi Bahram Rashidkhani Robabeh Taheripanah |
| author_sort | Seyed Mojtaba Ghoreishy |
| collection | DOAJ |
| description | Abstract Background Endometriosis, characterized as an inflammatory ailment, affects females during their reproductive years, leading to decreased quality of life. Despite the pivotal role of diet as a modifiable risk factor for various chronic conditions, its potential influence on endometriosis has remained inadequately explored. This research endeavor sought to scrutinize the association between dietary alternative healthy eating index, AHEI, and the likelihood of experiencing endometriosis among women in Iran. Methods Conducted as a hospital-centered case-control investigation, the study enlisted individuals diagnosed with endometriosis alongside healthy counterparts, confirmed by a gynecologist, between February and September 2021 in Tehran, Iran. The pattern of diet was assessed utilizing a validated Food Frequency Questionnaire (FFQ) encompassing 168 food items. Logistic regression models were employed to explore the potential connection between AHEI and the probability of endometriosis. Results The analysis encompassed 105 subjects with endometriosis and 208 individuals in good health. After adjustment for total calories intake (Kcal), occupation, smoking (yes/no), age at menarche (years), menstruation duration (days), regular menstruation (yes/no), physical activity (minutes per week) and familial history of endometriosis (yes/no), it was observed that those with the high adherence to the AHEI, had about 92% lower odds of endometriosis (Odds Ratio: 0.08, 95%Confidence Intervals: 0.03, 0.24; P for trend < 0.001). Conclusion The investigation illustrated a protective effect of healthy eating index and its components on developing endometriosis. |
| format | Article |
| id | doaj-art-7484792f170245d690f38b3f96d8a8b7 |
| institution | DOAJ |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj-art-7484792f170245d690f38b3f96d8a8b72025-08-20T03:08:44ZengBMCBMC Women's Health1472-68742025-05-0125111110.1186/s12905-025-03805-0Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control studySeyed Mojtaba Ghoreishy0Fatemeh Sadat Hashemi Javaheri1Sakine Ghasemisedaghat2Morvarid Noormohammadi3Ghazaleh Eslamian4Seyyedeh Neda Kazemi5Bahram Rashidkhani6Robabeh Taheripanah7Department of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Clinical Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical SciencesDepartment of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Men’s Health and Reproductive Health Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical SciencesAbstract Background Endometriosis, characterized as an inflammatory ailment, affects females during their reproductive years, leading to decreased quality of life. Despite the pivotal role of diet as a modifiable risk factor for various chronic conditions, its potential influence on endometriosis has remained inadequately explored. This research endeavor sought to scrutinize the association between dietary alternative healthy eating index, AHEI, and the likelihood of experiencing endometriosis among women in Iran. Methods Conducted as a hospital-centered case-control investigation, the study enlisted individuals diagnosed with endometriosis alongside healthy counterparts, confirmed by a gynecologist, between February and September 2021 in Tehran, Iran. The pattern of diet was assessed utilizing a validated Food Frequency Questionnaire (FFQ) encompassing 168 food items. Logistic regression models were employed to explore the potential connection between AHEI and the probability of endometriosis. Results The analysis encompassed 105 subjects with endometriosis and 208 individuals in good health. After adjustment for total calories intake (Kcal), occupation, smoking (yes/no), age at menarche (years), menstruation duration (days), regular menstruation (yes/no), physical activity (minutes per week) and familial history of endometriosis (yes/no), it was observed that those with the high adherence to the AHEI, had about 92% lower odds of endometriosis (Odds Ratio: 0.08, 95%Confidence Intervals: 0.03, 0.24; P for trend < 0.001). Conclusion The investigation illustrated a protective effect of healthy eating index and its components on developing endometriosis.https://doi.org/10.1186/s12905-025-03805-0Alternative healthy eating indexEndometriosisCase-control |
| spellingShingle | Seyed Mojtaba Ghoreishy Fatemeh Sadat Hashemi Javaheri Sakine Ghasemisedaghat Morvarid Noormohammadi Ghazaleh Eslamian Seyyedeh Neda Kazemi Bahram Rashidkhani Robabeh Taheripanah Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study BMC Women's Health Alternative healthy eating index Endometriosis Case-control |
| title | Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study |
| title_full | Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study |
| title_fullStr | Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study |
| title_full_unstemmed | Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study |
| title_short | Alternative healthy eating index may predict a reduced odd of endometriosis: results from a case-control study |
| title_sort | alternative healthy eating index may predict a reduced odd of endometriosis results from a case control study |
| topic | Alternative healthy eating index Endometriosis Case-control |
| url | https://doi.org/10.1186/s12905-025-03805-0 |
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