Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis
Abstract Objectives Several studies have shown a connection between periodontal diseases and conditions such as heart disease, diabetes, and pregnancy. This study aimed to investigate the relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC), Crohn’s disease (CD),...
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2025-08-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04181-7 |
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| author | Narges Naghsh Faezeh Karimi Moammad Javad Tarrahi Alireza Rahimi |
| author_facet | Narges Naghsh Faezeh Karimi Moammad Javad Tarrahi Alireza Rahimi |
| author_sort | Narges Naghsh |
| collection | DOAJ |
| description | Abstract Objectives Several studies have shown a connection between periodontal diseases and conditions such as heart disease, diabetes, and pregnancy. This study aimed to investigate the relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC), Crohn’s disease (CD), and periodontitis. Methods A systematic study was conducted in seven databases (PubMed, Scopus, Web of Science, ProQuest, Embase, Cochrane, and ScienceDirect) from 1960 to December 30, 2024. Articles investigating the relationship between periodontitis and IBD were selected based on established inclusion and exclusion criteria. The quality of the selected articles was assessed using the Newcastle-Ottawa checklist. The prevalence of periodontitis in individuals with and without IBD, as well as in each subgroup (UC and CD), was reported in terms of odds ratio (OR). Data analysis was conducted using Comprehensive Meta Analysis (CMA) software. Results Eleven studies were included in this systematic review. Statistical analysis of 10 studies revealed that, compared to the control group (without IBD), IBD patients had a significantly higher likelihood of periodontitis (OR: 2.28; 95% confidence interval [CI]: 1.73–3). Within each IBD subgroup, the likelihood of periodontitis was higher compared to the control group. The risk of developing periodontitis in patients diagnosed with UC and CD was found to be (OR: 3.14; 95% CI: 2.11–4.66) and (OR: 1.99; 95% CI: 1.4–2.83), respectively. However, this discrepancy was not statistically significant (P = 0.09). Conclusions IBD was associated with a higher likelihood of periodontitis compared to non-IBD patients. However, However, additional longitudinal research studies with larger sample sizes are necessary to validate this association and potentially reveal shared underlying mechanisms. |
| format | Article |
| id | doaj-art-7480b180980849d48548e10ae55e57ea |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-7480b180980849d48548e10ae55e57ea2025-08-24T11:33:06ZengBMCBMC Gastroenterology1471-230X2025-08-0125111910.1186/s12876-025-04181-7Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysisNarges Naghsh0Faezeh Karimi1Moammad Javad Tarrahi2Alireza Rahimi3Dental Implants Research Center, Department of Periodontics, School of Dentistry, Isfahan University of Medical SciencesDental Students’ Research Committee, School of Dentistry, Isfahan University of Medical SciencesDepartment of Biotatistics and Epidemiology, School of Health, Isfahan University of Medical SciencesHead of Clinical Informationist Research Group, Health Information Technology Research Center, Isfahan University of Medical SciencesAbstract Objectives Several studies have shown a connection between periodontal diseases and conditions such as heart disease, diabetes, and pregnancy. This study aimed to investigate the relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC), Crohn’s disease (CD), and periodontitis. Methods A systematic study was conducted in seven databases (PubMed, Scopus, Web of Science, ProQuest, Embase, Cochrane, and ScienceDirect) from 1960 to December 30, 2024. Articles investigating the relationship between periodontitis and IBD were selected based on established inclusion and exclusion criteria. The quality of the selected articles was assessed using the Newcastle-Ottawa checklist. The prevalence of periodontitis in individuals with and without IBD, as well as in each subgroup (UC and CD), was reported in terms of odds ratio (OR). Data analysis was conducted using Comprehensive Meta Analysis (CMA) software. Results Eleven studies were included in this systematic review. Statistical analysis of 10 studies revealed that, compared to the control group (without IBD), IBD patients had a significantly higher likelihood of periodontitis (OR: 2.28; 95% confidence interval [CI]: 1.73–3). Within each IBD subgroup, the likelihood of periodontitis was higher compared to the control group. The risk of developing periodontitis in patients diagnosed with UC and CD was found to be (OR: 3.14; 95% CI: 2.11–4.66) and (OR: 1.99; 95% CI: 1.4–2.83), respectively. However, this discrepancy was not statistically significant (P = 0.09). Conclusions IBD was associated with a higher likelihood of periodontitis compared to non-IBD patients. However, However, additional longitudinal research studies with larger sample sizes are necessary to validate this association and potentially reveal shared underlying mechanisms.https://doi.org/10.1186/s12876-025-04181-7Inflammatory bowel diseasesCrohn diseaseColitisUlcerativePeriodontitis |
| spellingShingle | Narges Naghsh Faezeh Karimi Moammad Javad Tarrahi Alireza Rahimi Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis BMC Gastroenterology Inflammatory bowel diseases Crohn disease Colitis Ulcerative Periodontitis |
| title | Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis |
| title_full | Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis |
| title_fullStr | Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis |
| title_full_unstemmed | Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis |
| title_short | Evaluation of the association between periodontitis and inflammatory bowel disease: A systematic review and Meta-analysis |
| title_sort | evaluation of the association between periodontitis and inflammatory bowel disease a systematic review and meta analysis |
| topic | Inflammatory bowel diseases Crohn disease Colitis Ulcerative Periodontitis |
| url | https://doi.org/10.1186/s12876-025-04181-7 |
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