Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/802701 |
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| author | Phani Krishna Kondamudi Hemalatha Kovelamudi Geetha Mathew Pawan G. Nayak Mallikarjuna C. Rao Rekha R. Shenoy |
| author_facet | Phani Krishna Kondamudi Hemalatha Kovelamudi Geetha Mathew Pawan G. Nayak Mallikarjuna C. Rao Rekha R. Shenoy |
| author_sort | Phani Krishna Kondamudi |
| collection | DOAJ |
| description | Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods. The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly (P<0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions. The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content. |
| format | Article |
| id | doaj-art-747f6e650534499185a04fa01e7e8b41 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-747f6e650534499185a04fa01e7e8b412025-08-20T02:07:28ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/802701802701Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino RatsPhani Krishna Kondamudi0Hemalatha Kovelamudi1Geetha Mathew2Pawan G. Nayak3Mallikarjuna C. Rao4Rekha R. Shenoy5Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaBackground. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods. The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly (P<0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions. The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.http://dx.doi.org/10.1155/2014/802701 |
| spellingShingle | Phani Krishna Kondamudi Hemalatha Kovelamudi Geetha Mathew Pawan G. Nayak Mallikarjuna C. Rao Rekha R. Shenoy Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats The Scientific World Journal |
| title | Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats |
| title_full | Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats |
| title_fullStr | Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats |
| title_full_unstemmed | Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats |
| title_short | Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats |
| title_sort | investigation of sesamol on myeloperoxidase and colon morphology in acetic acid induced inflammatory bowel disorder in albino rats |
| url | http://dx.doi.org/10.1155/2014/802701 |
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