Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment
Abstract The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial infections, hyperglycemia, and oxidative stress disrup...
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BMC
2025-05-01
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| Series: | Military Medical Research |
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| Online Access: | https://doi.org/10.1186/s40779-025-00611-5 |
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| author | Si-Jie Zhang Ran Xu Shao-Bin He Rong Sun Guan-Nan Wang Shu-Yi Wei Xi-Yun Yan Ke-Long Fan |
| author_facet | Si-Jie Zhang Ran Xu Shao-Bin He Rong Sun Guan-Nan Wang Shu-Yi Wei Xi-Yun Yan Ke-Long Fan |
| author_sort | Si-Jie Zhang |
| collection | DOAJ |
| description | Abstract The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial infections, hyperglycemia, and oxidative stress disrupt cellular functions and impair angiogenesis, substantially delaying wound repair. Nanozymes, which are engineered nanoscale materials with enzyme-like activities, offer distinct advantages over conventional enzymes and traditional nanomaterials, making them promising candidates for chronic wound treatment. To enhance their clinical potential, nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility, anti-oxidant activity, antibacterial efficacy, and tissue repair capabilities, ensuring their safety and clinical applicability. When integrated into multifunctional wound dressings, nanozymes modulate reactive oxygen species levels, promote tissue regeneration, and simultaneously combat infections and oxidative damage, extending beyond conventional enzyme-like catalysis in chronic wound treatment. The customizable architectures of nanozymes enable precise therapeutic applications, enhancing their effectiveness in managing complex wound conditions. This review provides a comprehensive analysis of the incorporation of nanozymes into wound dressings, detailing fabrication methods and emphasizing their transformative potential in chronic wound management. By identifying and addressing key limitations, we introduce strategic advancements to drive the development of nanozyme-driven dressings, paving the way for next-generation chronic wound treatments. |
| format | Article |
| id | doaj-art-747f4188959c4ab2bbfcecfd5d4a77e5 |
| institution | DOAJ |
| issn | 2054-9369 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj-art-747f4188959c4ab2bbfcecfd5d4a77e52025-08-20T03:20:05ZengBMCMilitary Medical Research2054-93692025-05-0112112610.1186/s40779-025-00611-5Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatmentSi-Jie Zhang0Ran Xu1Shao-Bin He2Rong Sun3Guan-Nan Wang4Shu-Yi Wei5Xi-Yun Yan6Ke-Long Fan7CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesCAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesCAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesDepartment of Radiation Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityShenyang Key Laboratory of Medical Molecular Theranostic Probes in School of Pharmacy, Shenyang Medical CollegePeking University People’s HospitalCAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesCAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesAbstract The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial infections, hyperglycemia, and oxidative stress disrupt cellular functions and impair angiogenesis, substantially delaying wound repair. Nanozymes, which are engineered nanoscale materials with enzyme-like activities, offer distinct advantages over conventional enzymes and traditional nanomaterials, making them promising candidates for chronic wound treatment. To enhance their clinical potential, nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility, anti-oxidant activity, antibacterial efficacy, and tissue repair capabilities, ensuring their safety and clinical applicability. When integrated into multifunctional wound dressings, nanozymes modulate reactive oxygen species levels, promote tissue regeneration, and simultaneously combat infections and oxidative damage, extending beyond conventional enzyme-like catalysis in chronic wound treatment. The customizable architectures of nanozymes enable precise therapeutic applications, enhancing their effectiveness in managing complex wound conditions. This review provides a comprehensive analysis of the incorporation of nanozymes into wound dressings, detailing fabrication methods and emphasizing their transformative potential in chronic wound management. By identifying and addressing key limitations, we introduce strategic advancements to drive the development of nanozyme-driven dressings, paving the way for next-generation chronic wound treatments.https://doi.org/10.1186/s40779-025-00611-5NanozymeEnzyme-like activitiesReactive oxygen species regulationChronic wound therapyMultifunctional wound dressing |
| spellingShingle | Si-Jie Zhang Ran Xu Shao-Bin He Rong Sun Guan-Nan Wang Shu-Yi Wei Xi-Yun Yan Ke-Long Fan Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment Military Medical Research Nanozyme Enzyme-like activities Reactive oxygen species regulation Chronic wound therapy Multifunctional wound dressing |
| title | Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment |
| title_full | Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment |
| title_fullStr | Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment |
| title_full_unstemmed | Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment |
| title_short | Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment |
| title_sort | nanozyme driven multifunctional dressings moving beyond enzyme like catalysis in chronic wound treatment |
| topic | Nanozyme Enzyme-like activities Reactive oxygen species regulation Chronic wound therapy Multifunctional wound dressing |
| url | https://doi.org/10.1186/s40779-025-00611-5 |
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