Systemic factors associated with antler growth promote complete wound healing
Abstract Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). This regeneration process starts from regenerative healing of wounds. Removal of PP abolishes antler regeneration, however, the regenerative cutaneous wound healing proceeds, indicatin...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Regenerative Medicine |
| Online Access: | https://doi.org/10.1038/s41536-025-00391-5 |
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| author | Qianqian Guo Guokun Zhang Jing Ren Jiping Li Zhen Wang Hengxing Ba Zihao Ye Ying Wang Junjun Zheng Chunyi Li |
| author_facet | Qianqian Guo Guokun Zhang Jing Ren Jiping Li Zhen Wang Hengxing Ba Zihao Ye Ying Wang Junjun Zheng Chunyi Li |
| author_sort | Qianqian Guo |
| collection | DOAJ |
| description | Abstract Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). This regeneration process starts from regenerative healing of wounds. Removal of PP abolishes antler regeneration, however, the regenerative cutaneous wound healing proceeds, indicating that some factors in the circulation contribute to this healing. In this study, we produced a wound in the scalp of deer either in antler regeneration period (ARP) (n = 3) or in non-ARP (n = 3). Results showed full regeneration took place only when the wound was created during ARP. Interestingly, topical application of systemic factors from ARP (n = 9) promoted regenerative wound healing in rats. Comparative proteomics analysis (n = 3) revealed that PRG4 and IGF-1 were high during ARP, and topical application of PRG4 + IGF-1 promoted restoration in rat FTE wounds. We believe that, ultimately, incorporating systemic factors into advanced wound care modalities could offer new opportunities for regenerative healing in the clinical setting. |
| format | Article |
| id | doaj-art-7479e28248a142ea96484ce52307a97a |
| institution | Kabale University |
| issn | 2057-3995 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Regenerative Medicine |
| spelling | doaj-art-7479e28248a142ea96484ce52307a97a2025-01-26T12:19:05ZengNature Portfolionpj Regenerative Medicine2057-39952025-01-0110111910.1038/s41536-025-00391-5Systemic factors associated with antler growth promote complete wound healingQianqian Guo0Guokun Zhang1Jing Ren2Jiping Li3Zhen Wang4Hengxing Ba5Zihao Ye6Ying Wang7Junjun Zheng8Chunyi Li9Institute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural SciencesInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityAbstract Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). This regeneration process starts from regenerative healing of wounds. Removal of PP abolishes antler regeneration, however, the regenerative cutaneous wound healing proceeds, indicating that some factors in the circulation contribute to this healing. In this study, we produced a wound in the scalp of deer either in antler regeneration period (ARP) (n = 3) or in non-ARP (n = 3). Results showed full regeneration took place only when the wound was created during ARP. Interestingly, topical application of systemic factors from ARP (n = 9) promoted regenerative wound healing in rats. Comparative proteomics analysis (n = 3) revealed that PRG4 and IGF-1 were high during ARP, and topical application of PRG4 + IGF-1 promoted restoration in rat FTE wounds. We believe that, ultimately, incorporating systemic factors into advanced wound care modalities could offer new opportunities for regenerative healing in the clinical setting.https://doi.org/10.1038/s41536-025-00391-5 |
| spellingShingle | Qianqian Guo Guokun Zhang Jing Ren Jiping Li Zhen Wang Hengxing Ba Zihao Ye Ying Wang Junjun Zheng Chunyi Li Systemic factors associated with antler growth promote complete wound healing npj Regenerative Medicine |
| title | Systemic factors associated with antler growth promote complete wound healing |
| title_full | Systemic factors associated with antler growth promote complete wound healing |
| title_fullStr | Systemic factors associated with antler growth promote complete wound healing |
| title_full_unstemmed | Systemic factors associated with antler growth promote complete wound healing |
| title_short | Systemic factors associated with antler growth promote complete wound healing |
| title_sort | systemic factors associated with antler growth promote complete wound healing |
| url | https://doi.org/10.1038/s41536-025-00391-5 |
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