Microdomain forming proteins in oncogenesis
Lipid rafts are lateral assembles of cholesterol, sphingomyelin, glicosphingolipids and specific proteins within cell plasma membrane. These microdomains are involved into a number of important cellular processes including membrane rearrangement, protein internalization, signal transduction, entry o...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2016-09-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/67 |
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| author | I. B. Zborovskaya S. A. Galetskiy A. V. Komel’kov |
| author_facet | I. B. Zborovskaya S. A. Galetskiy A. V. Komel’kov |
| author_sort | I. B. Zborovskaya |
| collection | DOAJ |
| description | Lipid rafts are lateral assembles of cholesterol, sphingomyelin, glicosphingolipids and specific proteins within cell plasma membrane. These microdomains are involved into a number of important cellular processes including membrane rearrangement, protein internalization, signal transduction, entry of viruses into the cell. Some of lipid rafts are stabilized by special microdomain-forming proteins such as caveolins, SPFH domain containing superfamily, tetraspanins, galectins, which maintain integrity of rafts and regulate signal transduction via forming of “signalosomes”. Involvement of the different lipid rafts is necessary in many situations such as binding of growth factors with their receptors, integrin regulation, cytoskeleton and extracellular matrix rearrangements, vesicular transport, etc. However, such classes of microdomain-forming proteins are still considered separately from each other. In this review we tried to perform complex analysis of microdomain-forming proteins in regulation of cancer assotiated processes. |
| format | Article |
| id | doaj-art-7477d5e4ae3d49cc84490fb6af4565ab |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-7477d5e4ae3d49cc84490fb6af4565ab2025-08-20T03:22:00ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872016-09-0133162910.17650/2313-805X-2016-3-3-16-2963Microdomain forming proteins in oncogenesisI. B. Zborovskaya0S. A. Galetskiy1A. V. Komel’kov2Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoye shosse, Moscow, 115478, RussiaResearch Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoye shosse, Moscow, 115478, RussiaResearch Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoye shosse, Moscow, 115478, RussiaLipid rafts are lateral assembles of cholesterol, sphingomyelin, glicosphingolipids and specific proteins within cell plasma membrane. These microdomains are involved into a number of important cellular processes including membrane rearrangement, protein internalization, signal transduction, entry of viruses into the cell. Some of lipid rafts are stabilized by special microdomain-forming proteins such as caveolins, SPFH domain containing superfamily, tetraspanins, galectins, which maintain integrity of rafts and regulate signal transduction via forming of “signalosomes”. Involvement of the different lipid rafts is necessary in many situations such as binding of growth factors with their receptors, integrin regulation, cytoskeleton and extracellular matrix rearrangements, vesicular transport, etc. However, such classes of microdomain-forming proteins are still considered separately from each other. In this review we tried to perform complex analysis of microdomain-forming proteins in regulation of cancer assotiated processes.https://umo.abvpress.ru/jour/article/view/67membrane microdomainsmicrodomain-forming proteinscaveolinflotillinstomatintetraspaningalectinsignal transductionexosomestumor progression |
| spellingShingle | I. B. Zborovskaya S. A. Galetskiy A. V. Komel’kov Microdomain forming proteins in oncogenesis Успехи молекулярной онкологии membrane microdomains microdomain-forming proteins caveolin flotillin stomatin tetraspanin galectin signal transduction exosomes tumor progression |
| title | Microdomain forming proteins in oncogenesis |
| title_full | Microdomain forming proteins in oncogenesis |
| title_fullStr | Microdomain forming proteins in oncogenesis |
| title_full_unstemmed | Microdomain forming proteins in oncogenesis |
| title_short | Microdomain forming proteins in oncogenesis |
| title_sort | microdomain forming proteins in oncogenesis |
| topic | membrane microdomains microdomain-forming proteins caveolin flotillin stomatin tetraspanin galectin signal transduction exosomes tumor progression |
| url | https://umo.abvpress.ru/jour/article/view/67 |
| work_keys_str_mv | AT ibzborovskaya microdomainformingproteinsinoncogenesis AT sagaletskiy microdomainformingproteinsinoncogenesis AT avkomelkov microdomainformingproteinsinoncogenesis |