An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China
Abstract Candidiasis poses a significant threat to human health, especially in immunocompromised patients. However, there is a paucity of epidemiological data concerning the prevalence of candidiasis in developing regions of China. We conducted a retrospective study on patients positive for Candida...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-92100-x |
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| author | Sabir Khan Lin Cai Hazrat Bilal Muhammad Nadeem Khan Wenjie Fang Dongxing Zhang Fen Yao Xun Wang Qian Wang Bing Hou Jiayue Wang Chunyan Mao Lingxi Liu Yuebin Zeng |
| author_facet | Sabir Khan Lin Cai Hazrat Bilal Muhammad Nadeem Khan Wenjie Fang Dongxing Zhang Fen Yao Xun Wang Qian Wang Bing Hou Jiayue Wang Chunyan Mao Lingxi Liu Yuebin Zeng |
| author_sort | Sabir Khan |
| collection | DOAJ |
| description | Abstract Candidiasis poses a significant threat to human health, especially in immunocompromised patients. However, there is a paucity of epidemiological data concerning the prevalence of candidiasis in developing regions of China. We conducted a retrospective study on patients positive for Candida infections in a tertiary care hospital in Shantou, China, to identify the clinical characteristics and risk factors for candidiasis. Of 5,095 cases of candidiasis, 489 (9.59%) were candidemia infections. Candida albicans (n = 230, 47.0%) was the predominant species identified among all patients. Non-albicans Candida (NAC) was more prevalent in adult patients, while Candida glabrata was slightly more frequent in pediatric patients (n = 10, 14.7%). Pulmonary diseases (n = 200, 47.8%) were the most common underlying comorbidities in adult patients (n = 25, 35.2%). Thrombocytopenia was the only laboratory finding higher in adult patients than in pediatric patients. Respiratory dysfunction, the presence of a central venous catheter, septic shock, and thrombocytopenia were independent risk factors for candidemia-related 30-day mortality. Amphotericin B exhibited high efficacy (100%), and itraconazole exhibited the lowest efficacy against all tested Candida isolates. C. glabrata had a lower susceptibility to azole, although this was not statistically significant. The epidemiological data on candidiasis, specifically candidemia in pediatric and adult patients, varied regarding the prevalence of Candida species and associated risk factors. This study provides guidance for prescribing the appropriate therapy and yields insights into the susceptibility patterns of different Candida isolates to antifungal drugs. |
| format | Article |
| id | doaj-art-7474d6abd44c41d7aa12e6a0176bfa8a |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-7474d6abd44c41d7aa12e6a0176bfa8a2025-08-20T02:01:30ZengNature PortfolioScientific Reports2045-23222025-02-0115111310.1038/s41598-025-92100-xAn 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in ChinaSabir Khan0Lin Cai1Hazrat Bilal2Muhammad Nadeem Khan3Wenjie Fang4Dongxing Zhang5Fen Yao6Xun Wang7Qian Wang8Bing Hou9Jiayue Wang10Chunyan Mao11Lingxi Liu12Yuebin Zeng13Department of Dermatology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Dermatology, Second Affiliated Hospital of Shantou University Medical CollegeJiangxi Key Laboratory of oncology, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Cancer Hospital, Jiangxi Cancer InstituteDeparment of Cell Biology and Genetics, Shantou University Medical CollegeDepartment of Dermatology, Changzheng Hospital, Second Military Medical UniversityDepartment of Dermatology, Meizhou Dongshan HospitalDepartment of Pharmacy, Shantou University School Medical CollegeDepartment of Dermatology, Second Affiliated Hospital of Shantou University Medical CollegeDepartment of Dermatology, Second Affiliated Hospital of Shantou University Medical CollegeDeparment of Clinical Laboratory, Skin and Venereal Diseases Prevention and Control Hospital of Shantou CityDepartment of Dermatology, West China Second University Hospital, Sichuan UniversityDepartment of Dermatology, West China Second University Hospital, Sichuan UniversityDepartment of Dermatology, West China Second University Hospital, Sichuan UniversityDepartment of Dermatology, Second Affiliated Hospital of Shantou University Medical CollegeAbstract Candidiasis poses a significant threat to human health, especially in immunocompromised patients. However, there is a paucity of epidemiological data concerning the prevalence of candidiasis in developing regions of China. We conducted a retrospective study on patients positive for Candida infections in a tertiary care hospital in Shantou, China, to identify the clinical characteristics and risk factors for candidiasis. Of 5,095 cases of candidiasis, 489 (9.59%) were candidemia infections. Candida albicans (n = 230, 47.0%) was the predominant species identified among all patients. Non-albicans Candida (NAC) was more prevalent in adult patients, while Candida glabrata was slightly more frequent in pediatric patients (n = 10, 14.7%). Pulmonary diseases (n = 200, 47.8%) were the most common underlying comorbidities in adult patients (n = 25, 35.2%). Thrombocytopenia was the only laboratory finding higher in adult patients than in pediatric patients. Respiratory dysfunction, the presence of a central venous catheter, septic shock, and thrombocytopenia were independent risk factors for candidemia-related 30-day mortality. Amphotericin B exhibited high efficacy (100%), and itraconazole exhibited the lowest efficacy against all tested Candida isolates. C. glabrata had a lower susceptibility to azole, although this was not statistically significant. The epidemiological data on candidiasis, specifically candidemia in pediatric and adult patients, varied regarding the prevalence of Candida species and associated risk factors. This study provides guidance for prescribing the appropriate therapy and yields insights into the susceptibility patterns of different Candida isolates to antifungal drugs.https://doi.org/10.1038/s41598-025-92100-xCandidiasisCandidemiaEpidemiologyRisk factorsAntifungal susceptibility |
| spellingShingle | Sabir Khan Lin Cai Hazrat Bilal Muhammad Nadeem Khan Wenjie Fang Dongxing Zhang Fen Yao Xun Wang Qian Wang Bing Hou Jiayue Wang Chunyan Mao Lingxi Liu Yuebin Zeng An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China Scientific Reports Candidiasis Candidemia Epidemiology Risk factors Antifungal susceptibility |
| title | An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China |
| title_full | An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China |
| title_fullStr | An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China |
| title_full_unstemmed | An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China |
| title_short | An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China |
| title_sort | 11 year retrospective analysis of candidiasis epidemiology risk factors and antifungal susceptibility in a tertiary care hospital in china |
| topic | Candidiasis Candidemia Epidemiology Risk factors Antifungal susceptibility |
| url | https://doi.org/10.1038/s41598-025-92100-x |
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