Impurity profiling of paracetamol toxic impurities in pharmaceutical combination with ibuprofen and chlorzoxazone using HPLC and TLC densitometric methods

Impurity profiling of paracetamol toxic impurities in pharmaceutical combination with ibuprofen and chlorzoxazone using HPLC and TLC densitometric methods

Abstract This work presents two methods for the simultaneous determination of ibuprofen (IBU), paracetamol (PAR), and chlorzoxazone (CHZ) in the presence of three PAR impurities: p-aminophenol (PAP), p-nitrophenol (PNP), and p-chloroacetanilide (PCA). Furthermore, both methods attempt to quantify th...

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Bibliographic Details
Main Authors: Israa A. Wahba, Said A. Hassan, Ahmed S. Fayed, Sally S. El-Mosallamy
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Chemistry
Subjects:
Chlorzoxazone
HPLC
Ibuprofen
Impurity profiling
Paracetamol
TLC densitometry
Online Access:https://doi.org/10.1186/s13065-025-01466-6
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