The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation
Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections. TLR4 has been long recognized as the...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6978936 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548892619571200 |
|---|---|
| author | Monica Molteni Sabrina Gemma Carlo Rossetti |
| author_facet | Monica Molteni Sabrina Gemma Carlo Rossetti |
| author_sort | Monica Molteni |
| collection | DOAJ |
| description | Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections. TLR4 has been long recognized as the sensing receptor for gram-negative lipopolysaccharide (LPS). In addition, it also binds endogenous molecules produced as a result of tissue injury. Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. This review focuses on the research progress about the role of TLR4 activation in infectious and noninfectious (e.g., sterile) inflammation and the effects of TLR4 signaling in some pathological conditions. |
| format | Article |
| id | doaj-art-746ea9783f9f42aa961c50a087130725 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-746ea9783f9f42aa961c50a0871307252025-02-03T06:12:46ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/69789366978936The Role of Toll-Like Receptor 4 in Infectious and Noninfectious InflammationMonica Molteni0Sabrina Gemma1Carlo Rossetti2Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell’Insubria, Via J. H. Dunant 3, 21100 Varese, ItalyDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell’Insubria, Via J. H. Dunant 3, 21100 Varese, ItalyDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell’Insubria, Via J. H. Dunant 3, 21100 Varese, ItalyToll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections. TLR4 has been long recognized as the sensing receptor for gram-negative lipopolysaccharide (LPS). In addition, it also binds endogenous molecules produced as a result of tissue injury. Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. This review focuses on the research progress about the role of TLR4 activation in infectious and noninfectious (e.g., sterile) inflammation and the effects of TLR4 signaling in some pathological conditions.http://dx.doi.org/10.1155/2016/6978936 |
| spellingShingle | Monica Molteni Sabrina Gemma Carlo Rossetti The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation Mediators of Inflammation |
| title | The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation |
| title_full | The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation |
| title_fullStr | The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation |
| title_full_unstemmed | The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation |
| title_short | The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation |
| title_sort | role of toll like receptor 4 in infectious and noninfectious inflammation |
| url | http://dx.doi.org/10.1155/2016/6978936 |
| work_keys_str_mv | AT monicamolteni theroleoftolllikereceptor4ininfectiousandnoninfectiousinflammation AT sabrinagemma theroleoftolllikereceptor4ininfectiousandnoninfectiousinflammation AT carlorossetti theroleoftolllikereceptor4ininfectiousandnoninfectiousinflammation AT monicamolteni roleoftolllikereceptor4ininfectiousandnoninfectiousinflammation AT sabrinagemma roleoftolllikereceptor4ininfectiousandnoninfectiousinflammation AT carlorossetti roleoftolllikereceptor4ininfectiousandnoninfectiousinflammation |