Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro
The degradation characteristics of high-purity (HP) magnesium (Mg) orthopedic implants under static and cyclic compressive loads (SCL and CCL) remain inadequately understood. This study developed an in vivo loading device capable of applying single SCL and CCL while shielding against unpredictable h...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-04-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724004092 |
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| author | Long Guo Xuanbin Zhang Zhishan Zhang Zhixiu Hao |
| author_facet | Long Guo Xuanbin Zhang Zhishan Zhang Zhixiu Hao |
| author_sort | Long Guo |
| collection | DOAJ |
| description | The degradation characteristics of high-purity (HP) magnesium (Mg) orthopedic implants under static and cyclic compressive loads (SCL and CCL) remain inadequately understood. This study developed an in vivo loading device capable of applying single SCL and CCL while shielding against unpredictable host movements. In vitro degradation experiments of HP Mg implants were conducted to verify the experimental protocol, and in vivo experiments in rabbit tibiae to observe the degradation characteristics of the implants. Micro-computed tomography and scanning electron microscope were used for three-dimensional reconstruction and surface morphology analysis, respectively. Compared to in vitro specimens, in vivo specimens exhibited significantly higher corrosion rates and more extensive cracking. Cracks in the in vivo specimens gradually penetrated deeper from the loading surface, eventually leading to a rapid structural deterioration; whereas in vitro specimens exhibited more surface-localized cracking and a relatively uniform corrosion pattern. Compared to SCL, CCL accelerated both corrosion and cracking to some extent. These findings provide new insights into the in vivo degradation behavior of Mg-based implants under compressive loading conditions. |
| format | Article |
| id | doaj-art-746b04897cc34e58a5963f4475bb608a |
| institution | OA Journals |
| issn | 2213-9567 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-746b04897cc34e58a5963f4475bb608a2025-08-20T02:13:44ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672025-04-011341480149410.1016/j.jma.2024.12.014Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitroLong Guo0Xuanbin Zhang1Zhishan Zhang2Zhixiu Hao3Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, PR ChinaDepartment of Mechanical Engineering, Tsinghua University, Beijing, 100084, PR ChinaDepartment of Orthopedics, Peking University Third Hospital, Beijing, 100191, PR ChinaState Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, PR China; Corresponding author.The degradation characteristics of high-purity (HP) magnesium (Mg) orthopedic implants under static and cyclic compressive loads (SCL and CCL) remain inadequately understood. This study developed an in vivo loading device capable of applying single SCL and CCL while shielding against unpredictable host movements. In vitro degradation experiments of HP Mg implants were conducted to verify the experimental protocol, and in vivo experiments in rabbit tibiae to observe the degradation characteristics of the implants. Micro-computed tomography and scanning electron microscope were used for three-dimensional reconstruction and surface morphology analysis, respectively. Compared to in vitro specimens, in vivo specimens exhibited significantly higher corrosion rates and more extensive cracking. Cracks in the in vivo specimens gradually penetrated deeper from the loading surface, eventually leading to a rapid structural deterioration; whereas in vitro specimens exhibited more surface-localized cracking and a relatively uniform corrosion pattern. Compared to SCL, CCL accelerated both corrosion and cracking to some extent. These findings provide new insights into the in vivo degradation behavior of Mg-based implants under compressive loading conditions.http://www.sciencedirect.com/science/article/pii/S2213956724004092Magnesium implantDegradable characteristicCompressive loadsIn vivo experimentIn vitro experimentGalvanic corrosion |
| spellingShingle | Long Guo Xuanbin Zhang Zhishan Zhang Zhixiu Hao Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro Journal of Magnesium and Alloys Magnesium implant Degradable characteristic Compressive loads In vivo experiment In vitro experiment Galvanic corrosion |
| title | Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro |
| title_full | Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro |
| title_fullStr | Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro |
| title_full_unstemmed | Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro |
| title_short | Degradation characteristics of high-purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro |
| title_sort | degradation characteristics of high purity magnesium implants under single static and cyclic compressive loads in vivo and in vitro |
| topic | Magnesium implant Degradable characteristic Compressive loads In vivo experiment In vitro experiment Galvanic corrosion |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724004092 |
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