Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

Abstract Candida albicans is the most common cause of life-threatening fungal infection in the developed world but remains a therapeutic challenge. Protein kinases have been rewarding drug targets across diverse indications but remain untapped for antifungal development. Previously, screening kinase...

Full description

Saved in:
Bibliographic Details
Main Authors: Emily Puumala, Meganathan Nandakumar, Bonnie Yiu, Peter J. Stogios, Benjamin G. Strickland, Robert Zarnowski, Xiaoyu Wang, Noelle S. Williams, Alexei Savchenko, David R. Andes, Nicole Robbins, Luke Whitesell, Timothy M. Willson, Leah E. Cowen
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57346-z
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items