Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

Ethyl pyruvate (EP) has demonstrated neuroprotective effects against acute brain injury through its anti-inflammatory action. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from dying cells. This study was designed to investigate the protective...

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Bibliographic Details
Main Authors:	Xingfen Su, Handong Wang, Jinbing Zhao, Hao Pan, Lei Mao
Format:	Article
Language:	English
Published:	Wiley 2011-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2011/807142
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