miR-340-5p alleviates the damage effect of LPS on nucleus pulposus cells by negatively regulating the expression of SOX4

miR-340-5p alleviates the damage effect of LPS on nucleus pulposus cells by negatively regulating the expression of SOX4

Abstract Background Previous studies show that about 80% of lumbar disc degeneration (LDD) patients experience back or leg pain, affecting their quality of life. However, the causes of LDD are not fully understood. This study focused on exploring the expression level of miR-340-5p and SRY-related hi...

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Bibliographic Details
Main Authors: Yuhang Liu, Lina Huang, Zhengtian Gao, Yingnuo Hou, Fanlei Kong, Shibin Hou, Zheng Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
miR-340-5p
SOX4
Lumbar disc degeneration
Inflammation
Extracellular matrix
Online Access:https://doi.org/10.1186/s13018-025-06069-4
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