An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents
Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives. The present work describes the synthesis of several oxazolidinone derivatives, 3-(2-(7-c...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/252187 |
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| author | Kavita Devi Yumna Asmat Sonika Jain Swapnil Sharma Jaya Dwivedi |
| author_facet | Kavita Devi Yumna Asmat Sonika Jain Swapnil Sharma Jaya Dwivedi |
| author_sort | Kavita Devi |
| collection | DOAJ |
| description | Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives. The present work describes the synthesis of several oxazolidinone derivatives, 3-(2-(7-chloroquinoline-4-ylamino)ethyl)-2-imino-5-(4-chloro/nitro/methoxy benzylidene)oxazolidin-4-one 4(a–c) and 4-(2-(7-chloroquinolin-4-ylamino)ethyl)-2(4-chloro/nitro/methoxy-benzylidene)-1,6-diox-4,9-di-azaspiro[4,4]nonane-3,8-dione 5(a–c). Synthesized compounds (1, 3, 4a, 5a, and 5c) were screened against bacterial strains such as S. aureus (MTCC 96) and E. coli (MTCC119)
and fungal strains A. niger (MTCC 1344) and C. albicans (MTCC 871) compared with penicillin for bacteria and fluconazole for fungi as reference drugs by disk diffusion method. All synthesized compounds were identified by the means of IR, NMR, and MS. |
| format | Article |
| id | doaj-art-744f499868d543db8af39001619e4de6 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-744f499868d543db8af39001619e4de62025-02-03T05:47:56ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/252187252187An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial AgentsKavita Devi0Yumna Asmat1Sonika Jain2Swapnil Sharma3Jaya Dwivedi4Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaDepartment of Pharmacy, Banasthali University, Banasthali 304022, IndiaDepartment of Chemistry, Banasthali University, Banasthali 304022, IndiaOxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives. The present work describes the synthesis of several oxazolidinone derivatives, 3-(2-(7-chloroquinoline-4-ylamino)ethyl)-2-imino-5-(4-chloro/nitro/methoxy benzylidene)oxazolidin-4-one 4(a–c) and 4-(2-(7-chloroquinolin-4-ylamino)ethyl)-2(4-chloro/nitro/methoxy-benzylidene)-1,6-diox-4,9-di-azaspiro[4,4]nonane-3,8-dione 5(a–c). Synthesized compounds (1, 3, 4a, 5a, and 5c) were screened against bacterial strains such as S. aureus (MTCC 96) and E. coli (MTCC119) and fungal strains A. niger (MTCC 1344) and C. albicans (MTCC 871) compared with penicillin for bacteria and fluconazole for fungi as reference drugs by disk diffusion method. All synthesized compounds were identified by the means of IR, NMR, and MS.http://dx.doi.org/10.1155/2013/252187 |
| spellingShingle | Kavita Devi Yumna Asmat Sonika Jain Swapnil Sharma Jaya Dwivedi An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents Journal of Chemistry |
| title | An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents |
| title_full | An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents |
| title_fullStr | An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents |
| title_full_unstemmed | An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents |
| title_short | An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents |
| title_sort | efficient approach to the synthesis of novel oxazolidinones as potential antimicrobial agents |
| url | http://dx.doi.org/10.1155/2013/252187 |
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