Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats
Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was re...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/1270483 |
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| author | Sebastian Marciniak Artur Wnorowski Katarzyna Smolińska Beata Walczyna Waldemar Turski Tomasz Kocki Piotr Paluszkiewicz Jolanta Parada-Turska |
| author_facet | Sebastian Marciniak Artur Wnorowski Katarzyna Smolińska Beata Walczyna Waldemar Turski Tomasz Kocki Piotr Paluszkiewicz Jolanta Parada-Turska |
| author_sort | Sebastian Marciniak |
| collection | DOAJ |
| description | Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested. |
| format | Article |
| id | doaj-art-744b4f54baf943c78cd0dea0f567dd0c |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-744b4f54baf943c78cd0dea0f567dd0c2025-02-03T01:26:38ZengWileyAnalytical Cellular Pathology2210-71772210-71852018-01-01201810.1155/2018/12704831270483Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in RatsSebastian Marciniak0Artur Wnorowski1Katarzyna Smolińska2Beata Walczyna3Waldemar Turski4Tomasz Kocki5Piotr Paluszkiewicz6Jolanta Parada-Turska7Department of Pharmacology, Medical University, Chodźki 4a Street, 20-093 Lublin, PolandDepartment of Biopharmacy, Medical University, Chodźki 4a Street, 23-093 Lublin, PolandDepartment of Surgery and Surgical Nursing, Medical University, Szkolna 18 Street, 20-124 Lublin, PolandDepartment of Clinical Pathomorphology, Medical University, Jaczewskiego 8b Street, 20-090 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b Street, 20-090 Lublin, PolandDepartment of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b Street, 20-090 Lublin, PolandDepartment of Surgery and Surgical Nursing, Medical University, Szkolna 18 Street, 20-124 Lublin, PolandDepartment of Rheumatology and Connective Tissue Diseases, Medical University, Jaczewskiego 8 Street, 20-090 Lublin, PolandAcute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and its potential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liver failure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well as the measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuation of morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumor necrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) - induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure was documented and the use of KYNA in the treatment of ALF was suggested.http://dx.doi.org/10.1155/2018/1270483 |
| spellingShingle | Sebastian Marciniak Artur Wnorowski Katarzyna Smolińska Beata Walczyna Waldemar Turski Tomasz Kocki Piotr Paluszkiewicz Jolanta Parada-Turska Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats Analytical Cellular Pathology |
| title | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
| title_full | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
| title_fullStr | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
| title_full_unstemmed | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
| title_short | Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats |
| title_sort | kynurenic acid protects against thioacetamide induced liver injury in rats |
| url | http://dx.doi.org/10.1155/2018/1270483 |
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