Salivary Biomarker Levels in Children with Sleep Problems Before and After Twin Block Therapy
Background: Disturbances in sleep have a wide-ranging effect on a child’s life profoundly impacting the standard of living. The aim of this study was to investigate levels of Salivary Tumor Necrosis Factor-Alpha (TNF-α) and Malondialdehyde (MDA) in a group of children with class II malocclusion and...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-10-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijdr.ijdr_88_23 |
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| Summary: | Background:
Disturbances in sleep have a wide-ranging effect on a child’s life profoundly impacting the standard of living. The aim of this study was to investigate levels of Salivary Tumor Necrosis Factor-Alpha (TNF-α) and Malondialdehyde (MDA) in a group of children with class II malocclusion and sleep problems before and after twin block appliance therapy.
Materials and Methods:
Eleven children aged 8–12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study. All children were subjected to a recording of their sleep history and a clinical and radiographic examination. Pre-treatment levels of salivary TNF-α and MDA were recorded. A twin block appliance was custom made and delivered to every child. After a minimum follow-up period of 9 months, all children were recalled for a re-evaluation of salivary biomarker levels.
Results:
Levels of salivary biomarkers TNF-α and MDA significantly decreased in children following myofunctional therapy using a twin block appliance.
Conclusion:
The measurement of TNF-α and MDA could be used as an alternative and noninvasive method to evaluate prognosis of twin block therapy for children with sleep-disordered breathing (SDB). |
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| ISSN: | 0970-9290 1998-3603 |