Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars
Abstract Devices capable of recording electrophysiological signals with high signal‐to‐noise ratio (SNR) and spatiotemporal resolution are crucial in neurological research. The introduction of flexible materials and conductive polymers in the fabrication of multi electrode arrays (MEAs) for electroc...
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| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202500051 |
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| author | Alice Lunghi Michele Bianchi Pierpaolo Greco Riccardo Viaro Michele Di Lauro Luciano Fadiga Fabio Biscarini |
| author_facet | Alice Lunghi Michele Bianchi Pierpaolo Greco Riccardo Viaro Michele Di Lauro Luciano Fadiga Fabio Biscarini |
| author_sort | Alice Lunghi |
| collection | DOAJ |
| description | Abstract Devices capable of recording electrophysiological signals with high signal‐to‐noise ratio (SNR) and spatiotemporal resolution are crucial in neurological research. The introduction of flexible materials and conductive polymers in the fabrication of multi electrode arrays (MEAs) for electrocorticography (ECoG) enabled higher quality of recorded signals thanks to device conformability and to low‐impedance electrodes. Advances in microfabrication techniques allow a dramatic reduction in electrode size, leading to highly‐dense microelectrode arrays with increased spatial resolution. Here, the synergic contribution of surface micropatterning and of conductive polymers on the recording performance of a home‐built µECoG device is explored. The device is fabricated through a combination of conventional and unconventional micropatterning techniques, leading to an ultra‐conformable polydimethylsiloxane (PDMS) array featuring different‐size flexible micropillars forests coated with a thin layer of poly(3,4‐ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS). The performance of the device is assessed in vitro by electrochemical impedance spectroscopy and in vivo by detecting somatosensory evoked potentials from the somatosensory cortex of a rat. The increasing of the geometric area has only limited effect on the recording capability in the in vivo model investigated. Nevertheless, the extremely high SNR values obtained place the proposed approach as an innovative and versatile strategy for the prototyping of ultra‐conformable µECoG devices. |
| format | Article |
| id | doaj-art-7444ecf4120f4ba2b67d9f0e2807960c |
| institution | Kabale University |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
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| series | Advanced Materials Interfaces |
| spelling | doaj-art-7444ecf4120f4ba2b67d9f0e2807960c2025-08-20T03:30:04ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-06-011212n/an/a10.1002/admi.202500051Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS MicropillarsAlice Lunghi0Michele Bianchi1Pierpaolo Greco2Riccardo Viaro3Michele Di Lauro4Luciano Fadiga5Fabio Biscarini6Department of Physics Mathematics and Informatics Università di Modena and Reggio Emilia Modena 41125 ItalyDepartment of Life Sciences University of Modena e Reggio Emilia Modena 41125 ItalySection of Physiology Department of Neuroscience and Rehabilitation University of Ferrara Ferrara 44121 ItalySection of Physiology Department of Neuroscience and Rehabilitation University of Ferrara Ferrara 44121 ItalyCentre for Translational Neurophysiology of Speech and Communication Italian Institute of Technology Ferrara 44121 ItalyCentre for Translational Neurophysiology of Speech and Communication Italian Institute of Technology Ferrara 44121 ItalyCentre for Translational Neurophysiology of Speech and Communication Italian Institute of Technology Ferrara 44121 ItalyAbstract Devices capable of recording electrophysiological signals with high signal‐to‐noise ratio (SNR) and spatiotemporal resolution are crucial in neurological research. The introduction of flexible materials and conductive polymers in the fabrication of multi electrode arrays (MEAs) for electrocorticography (ECoG) enabled higher quality of recorded signals thanks to device conformability and to low‐impedance electrodes. Advances in microfabrication techniques allow a dramatic reduction in electrode size, leading to highly‐dense microelectrode arrays with increased spatial resolution. Here, the synergic contribution of surface micropatterning and of conductive polymers on the recording performance of a home‐built µECoG device is explored. The device is fabricated through a combination of conventional and unconventional micropatterning techniques, leading to an ultra‐conformable polydimethylsiloxane (PDMS) array featuring different‐size flexible micropillars forests coated with a thin layer of poly(3,4‐ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS). The performance of the device is assessed in vitro by electrochemical impedance spectroscopy and in vivo by detecting somatosensory evoked potentials from the somatosensory cortex of a rat. The increasing of the geometric area has only limited effect on the recording capability in the in vivo model investigated. Nevertheless, the extremely high SNR values obtained place the proposed approach as an innovative and versatile strategy for the prototyping of ultra‐conformable µECoG devices.https://doi.org/10.1002/admi.202500051conductive polymerselectrodepositionepicortical recordingmicrofabricationPDMSsomatosensory evoked potential |
| spellingShingle | Alice Lunghi Michele Bianchi Pierpaolo Greco Riccardo Viaro Michele Di Lauro Luciano Fadiga Fabio Biscarini Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars Advanced Materials Interfaces conductive polymers electrodeposition epicortical recording microfabrication PDMS somatosensory evoked potential |
| title | Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars |
| title_full | Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars |
| title_fullStr | Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars |
| title_full_unstemmed | Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars |
| title_short | Ultra‐Flexible µ‐ECoG Arrays Based on PEDOT:PSS Micropillars |
| title_sort | ultra flexible µ ecog arrays based on pedot pss micropillars |
| topic | conductive polymers electrodeposition epicortical recording microfabrication PDMS somatosensory evoked potential |
| url | https://doi.org/10.1002/admi.202500051 |
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