Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production

Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production

Abstract Gut microbiota-derived short-chain fatty acids (SCFAs) impact asthma outcomes, highlighting the importance of understanding the disease mechanisms through the gut–lung axis. In this study, we identified that among SCFAs, butyrate uniquely alleviates asthma through specifically inhibiting a...

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Main Authors: Baichao Yu, Chong Pei, Wenjun Peng, Yongkun Zheng, Ying Fu, Xueqi Wang, Wenjun Wang, Zhiqiang Wang, Yong Chen, Qi Wang, Kameina Zhuma, Yiyuan Gao, Yun Xing, Mengxia Jiao, Ronghua Liu, Feifei Luo, Dan Zhang, Jingbo Qie, Hui Yang, Meiling Jin, Luman Wang, Yiwei Chu
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02263-2
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