Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD
Cognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson’s disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-d...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/6278649 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556072371486720 |
|---|---|
| author | Kai Li Wen Su Shu-Hua Li Ying Jin Hai-Bo Chen |
| author_facet | Kai Li Wen Su Shu-Hua Li Ying Jin Hai-Bo Chen |
| author_sort | Kai Li |
| collection | DOAJ |
| description | Cognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson’s disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-developing research field, and its application in cognitive impairments in PD is rapidly growing. In this review, we summarize rs-fMRI studies on cognitive function in PD and discuss the strong potential of rs-fMRI in this area. rs-fMRI can help reveal the pathophysiology of cognitive symptoms in PD, facilitate early identification of PD patients with cognitive impairment, distinguish PD dementia from dementia with Lewy bodies, and monitor and guide treatment for cognitive impairment in PD. In particular, ongoing and future longitudinal studies would enhance the ability of rs-fMRI in predicting PD dementia. In combination with other modalities such as positron emission tomography, rs-fMRI could give us more information on the underlying mechanism of cognitive deficits in PD. |
| format | Article |
| id | doaj-art-7443e32dd9b04f2785e521d601580300 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-7443e32dd9b04f2785e521d6015803002025-02-03T05:46:22ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/62786496278649Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PDKai Li0Wen Su1Shu-Hua Li2Ying Jin3Hai-Bo Chen4Department of Neurology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, ChinaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, ChinaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, ChinaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, ChinaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730, ChinaCognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson’s disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-developing research field, and its application in cognitive impairments in PD is rapidly growing. In this review, we summarize rs-fMRI studies on cognitive function in PD and discuss the strong potential of rs-fMRI in this area. rs-fMRI can help reveal the pathophysiology of cognitive symptoms in PD, facilitate early identification of PD patients with cognitive impairment, distinguish PD dementia from dementia with Lewy bodies, and monitor and guide treatment for cognitive impairment in PD. In particular, ongoing and future longitudinal studies would enhance the ability of rs-fMRI in predicting PD dementia. In combination with other modalities such as positron emission tomography, rs-fMRI could give us more information on the underlying mechanism of cognitive deficits in PD.http://dx.doi.org/10.1155/2018/6278649 |
| spellingShingle | Kai Li Wen Su Shu-Hua Li Ying Jin Hai-Bo Chen Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD Parkinson's Disease |
| title | Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD |
| title_full | Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD |
| title_fullStr | Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD |
| title_full_unstemmed | Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD |
| title_short | Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD |
| title_sort | resting state fmri a valuable tool for studying cognitive dysfunction in pd |
| url | http://dx.doi.org/10.1155/2018/6278649 |
| work_keys_str_mv | AT kaili restingstatefmriavaluabletoolforstudyingcognitivedysfunctioninpd AT wensu restingstatefmriavaluabletoolforstudyingcognitivedysfunctioninpd AT shuhuali restingstatefmriavaluabletoolforstudyingcognitivedysfunctioninpd AT yingjin restingstatefmriavaluabletoolforstudyingcognitivedysfunctioninpd AT haibochen restingstatefmriavaluabletoolforstudyingcognitivedysfunctioninpd |