Efficacy and safety of local–regional therapy combined with chemotherapy, immune checkpoint inhibitors and lenvatinib as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter retrospective cohort study

Efficacy and safety of local–regional therapy combined with chemotherapy, immune checkpoint inhibitors and lenvatinib as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter retrospective cohort study

Abstract Background Local–regional therapy combined with immune checkpoint inhibitors (ICIs) and lenvatinib has shown promising anti-tumor activity in advanced biliary tract cancer. However, the efficacy and safety of integrating local–regional therapy with chemotherapy, ICIs, and lenvatinib in adva...

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Main Authors: Shuofeng Li, Guanhua Yu, Mingming Wang, Shi Feng, Shanshan Wang, Mingjian Piao, Chengjie Li, Zixiang Zhou, Ziyu Xun, Boyu Sun, Jiongyuan Li, Nan Zhang, Hu Li, Xiaobo Yang, Zhenyu Zhu, Haitao Zhao
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Intrahepatic cholangiocarcinoma
Local–regional therapy
Chemotherapy
Immunotherapy
Targeted therapy
Online Access:https://doi.org/10.1007/s00262-025-04085-1
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