Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report
Adult onset hemophagocytic lymphohistiocytosis (HLH) is a rare condition, usually secondary to either a precipitating infective or hematologic malignancy. We present a case of Epstein–Barr virus associated HLH in a 55-year-old female receiving treatment for a glioblastoma (GBM). It is possible that...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | CNS Oncology |
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| Online Access: | https://www.futuremedicine.com/doi/10.2217/cns-2019-0013 |
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| author | Vaibhav Kumar Patrick J Eulitt Ana Bermudez Simon Khagi |
| author_facet | Vaibhav Kumar Patrick J Eulitt Ana Bermudez Simon Khagi |
| author_sort | Vaibhav Kumar |
| collection | DOAJ |
| description | Adult onset hemophagocytic lymphohistiocytosis (HLH) is a rare condition, usually secondary to either a precipitating infective or hematologic malignancy. We present a case of Epstein–Barr virus associated HLH in a 55-year-old female receiving treatment for a glioblastoma (GBM). It is possible that HLH is under recognized, as patients with GBM often have features of a nonspecific systemic inflammatory response syndrome, multiorgan failure and cognitive decline. A high index of suspicion and increased awareness can help improve timeliness of diagnosis. Therapeutically, Epstein–Barr virus associated HLH in patients with solid organ malignancy poses significant challenges. An individualized, multidisciplinary approach is essential when managing adult-onset HLH and providers will need to be mindful of the high mortality rate despite treatment. |
| format | Article |
| id | doaj-art-742d707b4d124000a6c529d489193864 |
| institution | OA Journals |
| issn | 2045-0907 2045-0915 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CNS Oncology |
| spelling | doaj-art-742d707b4d124000a6c529d4891938642025-08-20T02:26:02ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152019-12-018410.2217/cns-2019-0013Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case reportVaibhav Kumar0Patrick J Eulitt1Ana Bermudez2Simon Khagi31Division of Hematology & Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA1Division of Hematology & Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA2Division of Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA1Division of Hematology & Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAAdult onset hemophagocytic lymphohistiocytosis (HLH) is a rare condition, usually secondary to either a precipitating infective or hematologic malignancy. We present a case of Epstein–Barr virus associated HLH in a 55-year-old female receiving treatment for a glioblastoma (GBM). It is possible that HLH is under recognized, as patients with GBM often have features of a nonspecific systemic inflammatory response syndrome, multiorgan failure and cognitive decline. A high index of suspicion and increased awareness can help improve timeliness of diagnosis. Therapeutically, Epstein–Barr virus associated HLH in patients with solid organ malignancy poses significant challenges. An individualized, multidisciplinary approach is essential when managing adult-onset HLH and providers will need to be mindful of the high mortality rate despite treatment.https://www.futuremedicine.com/doi/10.2217/cns-2019-0013Epstein–Barr virusglioblastomahemophagocytic lymphohistiocytosishyperferritinemiapancytopeniasplenomegaly |
| spellingShingle | Vaibhav Kumar Patrick J Eulitt Ana Bermudez Simon Khagi Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report CNS Oncology Epstein–Barr virus glioblastoma hemophagocytic lymphohistiocytosis hyperferritinemia pancytopenia splenomegaly |
| title | Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report |
| title_full | Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report |
| title_fullStr | Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report |
| title_full_unstemmed | Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report |
| title_short | Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report |
| title_sort | hemophagocytic lymphohistiocytosis in a patient with glioblastoma a case report |
| topic | Epstein–Barr virus glioblastoma hemophagocytic lymphohistiocytosis hyperferritinemia pancytopenia splenomegaly |
| url | https://www.futuremedicine.com/doi/10.2217/cns-2019-0013 |
| work_keys_str_mv | AT vaibhavkumar hemophagocyticlymphohistiocytosisinapatientwithglioblastomaacasereport AT patrickjeulitt hemophagocyticlymphohistiocytosisinapatientwithglioblastomaacasereport AT anabermudez hemophagocyticlymphohistiocytosisinapatientwithglioblastomaacasereport AT simonkhagi hemophagocyticlymphohistiocytosisinapatientwithglioblastomaacasereport |