Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS
Abstract Background Multiple sclerosis (MS) can significantly impact cognitive function. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in improving cognitive deficits in various neurological conditions. This study intended to examine the effectiveness of high-frequency rTMS i...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-05-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-025-00962-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850191041870692352 |
|---|---|
| author | Esraa Hasan Ebrahim Elsesy Rasha El Bialy El Sharkawy Marwa Abdellah Osman |
| author_facet | Esraa Hasan Ebrahim Elsesy Rasha El Bialy El Sharkawy Marwa Abdellah Osman |
| author_sort | Esraa Hasan Ebrahim Elsesy |
| collection | DOAJ |
| description | Abstract Background Multiple sclerosis (MS) can significantly impact cognitive function. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in improving cognitive deficits in various neurological conditions. This study intended to examine the effectiveness of high-frequency rTMS in improving cognitive deficits in patients with relapsing–remitting MS (RRMS) and secondary progressive MS (SPMS). Results Before treatment, MOCA scores were significantly lower in the SPMS group (17.53 ± 1.13) as compared to the RRMS group (21.13 ± 1.25; p ≤ 0.05). After rTMS, both groups exhibited significant improvement in MOCA scores, with the RRMS group improving to 28.93 ± 0.96 and the SPMS group improving to 23.67 ± 1.11 (both p ≤ 0.01). However, the magnitude of improvement was more significant in the RRMS group, with a mean improvement of 7.80 ± 1.37 (39.23% ± 7.52%) as compared to 6.13 ± 1.41 (32.81% ± 6.85%) in the SPMS group (p ≤ 0.01 for degree of improvement and p ≤ 0.01 for percentage improvement). Conclusion These findings suggest that high-frequency rTMS may be a beneficial therapeutic option for improving cognitive function in both RRMS and SPMS patients. However, the degree of cognitive enhancement may vary depending on the disease course. |
| format | Article |
| id | doaj-art-742cb92b868446c3bd5535b8ec71be5d |
| institution | OA Journals |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-742cb92b868446c3bd5535b8ec71be5d2025-08-20T02:15:02ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-05-016111610.1186/s41983-025-00962-9Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMSEsraa Hasan Ebrahim Elsesy0Rasha El Bialy El Sharkawy1Marwa Abdellah Osman2Menoufia UniversityAl Azhar UniversityAl Azhar UniversityAbstract Background Multiple sclerosis (MS) can significantly impact cognitive function. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in improving cognitive deficits in various neurological conditions. This study intended to examine the effectiveness of high-frequency rTMS in improving cognitive deficits in patients with relapsing–remitting MS (RRMS) and secondary progressive MS (SPMS). Results Before treatment, MOCA scores were significantly lower in the SPMS group (17.53 ± 1.13) as compared to the RRMS group (21.13 ± 1.25; p ≤ 0.05). After rTMS, both groups exhibited significant improvement in MOCA scores, with the RRMS group improving to 28.93 ± 0.96 and the SPMS group improving to 23.67 ± 1.11 (both p ≤ 0.01). However, the magnitude of improvement was more significant in the RRMS group, with a mean improvement of 7.80 ± 1.37 (39.23% ± 7.52%) as compared to 6.13 ± 1.41 (32.81% ± 6.85%) in the SPMS group (p ≤ 0.01 for degree of improvement and p ≤ 0.01 for percentage improvement). Conclusion These findings suggest that high-frequency rTMS may be a beneficial therapeutic option for improving cognitive function in both RRMS and SPMS patients. However, the degree of cognitive enhancement may vary depending on the disease course.https://doi.org/10.1186/s41983-025-00962-9Cognitive assessmentRTMSMultiple sclerosis |
| spellingShingle | Esraa Hasan Ebrahim Elsesy Rasha El Bialy El Sharkawy Marwa Abdellah Osman Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Cognitive assessment RTMS Multiple sclerosis |
| title | Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS |
| title_full | Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS |
| title_fullStr | Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS |
| title_full_unstemmed | Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS |
| title_short | Efficacy of high-frequency rTMS for cognitive impairment in multiple sclerosis: a comparative study of RRMS and SPMS |
| title_sort | efficacy of high frequency rtms for cognitive impairment in multiple sclerosis a comparative study of rrms and spms |
| topic | Cognitive assessment RTMS Multiple sclerosis |
| url | https://doi.org/10.1186/s41983-025-00962-9 |
| work_keys_str_mv | AT esraahasanebrahimelsesy efficacyofhighfrequencyrtmsforcognitiveimpairmentinmultiplesclerosisacomparativestudyofrrmsandspms AT rashaelbialyelsharkawy efficacyofhighfrequencyrtmsforcognitiveimpairmentinmultiplesclerosisacomparativestudyofrrmsandspms AT marwaabdellahosman efficacyofhighfrequencyrtmsforcognitiveimpairmentinmultiplesclerosisacomparativestudyofrrmsandspms |