LY6E as a new prognostic biomarker of multiple myeloma-related bone disease
Abstract Osteolytic bone disease, which deteriorates the quality of life, is a prevalent complication of multiple myeloma (MM). In this study, we utilized bioinformatics analysis to identify the differentially expressed genes (DEGs) associated with MM bone disease (MBD) from the Gene Expression Omni...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-91413-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850153663495929856 |
|---|---|
| author | Min Shi Jing Li Jing Wang Ye Yao Xuxing Shen Yuan Xia Ji Xu |
| author_facet | Min Shi Jing Li Jing Wang Ye Yao Xuxing Shen Yuan Xia Ji Xu |
| author_sort | Min Shi |
| collection | DOAJ |
| description | Abstract Osteolytic bone disease, which deteriorates the quality of life, is a prevalent complication of multiple myeloma (MM). In this study, we utilized bioinformatics analysis to identify the differentially expressed genes (DEGs) associated with MM bone disease (MBD) from the Gene Expression Omnibus (GEO) databases. Here, the Kaplan-Meier (K-M) curve and Cox regression analyses demonstrated that the key molecule lymphocyte antigen 6 complex (LY6E) was closely correlated with the MM progression, unfavorable prognosis and the formation of MBD. Furthermore, we confirmed that higher LY6E expression promoted MM cell proliferation and osteoclast differentiation in vitro. Taken together, these findings may illuminate the theoretical foundation for LY6E in MBD formation and identify it as a neoteric therapeutic target for MM. |
| format | Article |
| id | doaj-art-7426c77bfbda4ab9a30c5bd2f83d6d4b |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7426c77bfbda4ab9a30c5bd2f83d6d4b2025-08-20T02:25:40ZengNature PortfolioScientific Reports2045-23222025-04-0115111110.1038/s41598-025-91413-1LY6E as a new prognostic biomarker of multiple myeloma-related bone diseaseMin Shi0Jing Li1Jing Wang2Ye Yao3Xuxing Shen4Yuan Xia5Ji Xu6Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Hematology, the First Affiliated Hospital of Anhui University of Chinese MedicineDepartment of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Osteolytic bone disease, which deteriorates the quality of life, is a prevalent complication of multiple myeloma (MM). In this study, we utilized bioinformatics analysis to identify the differentially expressed genes (DEGs) associated with MM bone disease (MBD) from the Gene Expression Omnibus (GEO) databases. Here, the Kaplan-Meier (K-M) curve and Cox regression analyses demonstrated that the key molecule lymphocyte antigen 6 complex (LY6E) was closely correlated with the MM progression, unfavorable prognosis and the formation of MBD. Furthermore, we confirmed that higher LY6E expression promoted MM cell proliferation and osteoclast differentiation in vitro. Taken together, these findings may illuminate the theoretical foundation for LY6E in MBD formation and identify it as a neoteric therapeutic target for MM.https://doi.org/10.1038/s41598-025-91413-1LY6EMultiple myelomaBone diseaseOsteoclast |
| spellingShingle | Min Shi Jing Li Jing Wang Ye Yao Xuxing Shen Yuan Xia Ji Xu LY6E as a new prognostic biomarker of multiple myeloma-related bone disease Scientific Reports LY6E Multiple myeloma Bone disease Osteoclast |
| title | LY6E as a new prognostic biomarker of multiple myeloma-related bone disease |
| title_full | LY6E as a new prognostic biomarker of multiple myeloma-related bone disease |
| title_fullStr | LY6E as a new prognostic biomarker of multiple myeloma-related bone disease |
| title_full_unstemmed | LY6E as a new prognostic biomarker of multiple myeloma-related bone disease |
| title_short | LY6E as a new prognostic biomarker of multiple myeloma-related bone disease |
| title_sort | ly6e as a new prognostic biomarker of multiple myeloma related bone disease |
| topic | LY6E Multiple myeloma Bone disease Osteoclast |
| url | https://doi.org/10.1038/s41598-025-91413-1 |
| work_keys_str_mv | AT minshi ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease AT jingli ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease AT jingwang ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease AT yeyao ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease AT xuxingshen ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease AT yuanxia ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease AT jixu ly6easanewprognosticbiomarkerofmultiplemyelomarelatedbonedisease |