From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies

From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies

Background: Monoclonal antibodies (mAbs) are typically colorless; however, the pink coloration observed during production raises quality concerns. This study investigated the mechanism linking this color change to Vitamin B12 (VB12), which converts to hydroxycobalamin (OH-Cbl) under light and binds...

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Bibliographic Details
Main Authors: Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Medicine in Drug Discovery
Subjects:
Vitamin B12
Antibody color
Cysteine
Protein pocket
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098625000211
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