DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY
Aim. Using the data from the CHD PROGNOSIS register, to assess the long-term survival of patients with stable coronary heart disease (CHD) confirmed by a diagnostic coronary angiography (CAG).Material and methods. The study design (retro- and prospective observational cohort study) agreed with the r...
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«SILICEA-POLIGRAF» LLC
2013-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/107 |
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| author | S. N. Tolpygina S. Yu. Martsevich E. A. Gofman A. M. Malysheva Yu. N. Polyanskaya A. D. Deev |
| author_facet | S. N. Tolpygina S. Yu. Martsevich E. A. Gofman A. M. Malysheva Yu. N. Polyanskaya A. D. Deev |
| author_sort | S. N. Tolpygina |
| collection | DOAJ |
| description | Aim. Using the data from the CHD PROGNOSIS register, to assess the long-term survival of patients with stable coronary heart disease (CHD) confirmed by a diagnostic coronary angiography (CAG).Material and methods. The study design (retro- and prospective observational cohort study) agreed with the register principles. The study included all consecutive patients (Moscow Region residents) who were hospitalised to the State Research Centre for Preventive Medicine with a preliminary diagnosis of CHD, for a diagnostic CAG and therapeutic strategy selection (01.01.2004–31.12.2007). The total number of participants was 641 (500 men and 141 women). Vital status was ascertained in 551 patients (86%). Mean follow-up time was 3,8 years (range 0,76–6,52 years).Results. The register participants had a high prevalence of conventional risk factors and adverse clinical and anamnestic characteristics. CAGconfirmed coronary artery (CA) stenosis ≥50% was registered in 563 patients. In 24 out of 78 individuals with “intact” CA, coronary syndrome X or vasospastic angina was diagnosed; in the other 54, CHD diagnosis could not be confirmed. During the hospitalisation, balloon angioplasty was performed in 38% of the patients with known vital status. Before hospitalisation, the main drug classes with proven prognostic benefits were administered insufficiently often. During the follow-up period (mean follow-up 3,9 years), 50 patients died. All-cause mortality was 11,38±1,61 per 1000 person-years. The leading cause of death was chronic CHD (84%), which confirms high levels of cardiovascular risk in these patients. In total, fatal and non-fatal complications, including revascularisation episodes, were registered in 36%.Conclusion. The established register of stable CHD includes a typical cohort of chronic CHD patients who are referred for invasive diagnostics and treatment. Therefore, the register is expected to provide valid information on the factors determining prognosis and effectiveness of medical intervention, such as pharmacological therapy and percutaneous revascularisation. |
| format | Article |
| id | doaj-art-74215c3eb6834fd08d29520be1eb2eeb |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2013-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
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| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-74215c3eb6834fd08d29520be1eb2eeb2025-08-20T03:57:17Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252013-02-01121323910.15829/1728-8800-2013-1-32-39107DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDYS. N. Tolpygina0S. Yu. Martsevich1E. A. Gofman2A. M. Malysheva3Yu. N. Polyanskaya4A. D. Deev5State Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowState Research Centre for Preventive Medicine, MoscowAim. Using the data from the CHD PROGNOSIS register, to assess the long-term survival of patients with stable coronary heart disease (CHD) confirmed by a diagnostic coronary angiography (CAG).Material and methods. The study design (retro- and prospective observational cohort study) agreed with the register principles. The study included all consecutive patients (Moscow Region residents) who were hospitalised to the State Research Centre for Preventive Medicine with a preliminary diagnosis of CHD, for a diagnostic CAG and therapeutic strategy selection (01.01.2004–31.12.2007). The total number of participants was 641 (500 men and 141 women). Vital status was ascertained in 551 patients (86%). Mean follow-up time was 3,8 years (range 0,76–6,52 years).Results. The register participants had a high prevalence of conventional risk factors and adverse clinical and anamnestic characteristics. CAGconfirmed coronary artery (CA) stenosis ≥50% was registered in 563 patients. In 24 out of 78 individuals with “intact” CA, coronary syndrome X or vasospastic angina was diagnosed; in the other 54, CHD diagnosis could not be confirmed. During the hospitalisation, balloon angioplasty was performed in 38% of the patients with known vital status. Before hospitalisation, the main drug classes with proven prognostic benefits were administered insufficiently often. During the follow-up period (mean follow-up 3,9 years), 50 patients died. All-cause mortality was 11,38±1,61 per 1000 person-years. The leading cause of death was chronic CHD (84%), which confirms high levels of cardiovascular risk in these patients. In total, fatal and non-fatal complications, including revascularisation episodes, were registered in 36%.Conclusion. The established register of stable CHD includes a typical cohort of chronic CHD patients who are referred for invasive diagnostics and treatment. Therefore, the register is expected to provide valid information on the factors determining prognosis and effectiveness of medical intervention, such as pharmacological therapy and percutaneous revascularisation.https://cardiovascular.elpub.ru/jour/article/view/107registerobservational cohort studychronic coronary heart diseasecoronary angiographyprognosis |
| spellingShingle | S. N. Tolpygina S. Yu. Martsevich E. A. Gofman A. M. Malysheva Yu. N. Polyanskaya A. D. Deev DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY Кардиоваскулярная терапия и профилактика register observational cohort study chronic coronary heart disease coronary angiography prognosis |
| title | DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY |
| title_full | DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY |
| title_fullStr | DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY |
| title_full_unstemmed | DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY |
| title_short | DEVELOPING A REGISTER OF OUTCOMES OF CHRONIC CORONARY HEART DISEASE: CHD PROGNOSIS STUDY |
| title_sort | developing a register of outcomes of chronic coronary heart disease chd prognosis study |
| topic | register observational cohort study chronic coronary heart disease coronary angiography prognosis |
| url | https://cardiovascular.elpub.ru/jour/article/view/107 |
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