Impact of metagenomics next-generation sequencing on etiological diagnosis and early outcomes in sepsis

Impact of metagenomics next-generation sequencing on etiological diagnosis and early outcomes in sepsis

Abstract Background Clinical implications of metagenomics next-generation sequencing (mNGS) in sepsis have not been fully evaluated. This study aimed to determine the diagnostic, therapeutic, and prognostic impacts of mNGS in sepsis. Methods This multicenter prospective study was conducted at 19 sit...

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Main Authors: Feixiang Xu, Chen Chen, Su Lu, Mingming Xue, Hailin Ding, Yanli Song, Yun Zhang, Keyu Sun, Lunxian Tang, Wei Wang, Meitang Wang, Yan Tang, Dingyu Tan, Chenling Yao, Dongwei Shi, Enqiang Mao, Mian Shao, Youguo Ying, Chunmei Zhou, Lihong Huang, Hu Peng, Zhongshu Kuang, Sanqiang Wang, Qingbian Ma, Si Sun, Dongfeng Guo, Tianwen Gu, Bin Yang, Linhao Ma, Chengjin Gao, Xiaoye Lu, Hong Zhang, Ruilan Wang, Chaoyang Tong, Zhenju Song
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Sepsis
Metagenomics next-generation sequencing
Conventional microbiological test
Etiological diagnosis
Antibiotics
28-day mortality
Online Access:https://doi.org/10.1186/s12967-025-06332-6
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