DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome

DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome

Abstract Background G-quadruplex structures (G4s) have been identified in the genomes of many organisms and have been proven to play significant epigenetic regulatory roles in gene transcription. Intriguingly, only a small portion of the predicted G4-forming sequences can fold into G4s under cellula...

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Main Authors: Kangkang Niu, Lijun Xiang, Xiaojuan Zhang, Xiaoyu Li, Tingting Yao, Jin Li, Chu Zhang, Junpeng Liu, Yuling Peng, Guanfeng Xu, Hui Xiang, Hao Wang, Qisheng Song, Qili Feng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
DNA methylation
G-quadruplex formation
Epigenetic regulation
Gene expression
Online Access:https://doi.org/10.1186/s13059-025-03678-4
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